Evidence map›Paper›PMID 37466740›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2023

Twenty years of merotelic kinetochore attachments: a historical perspective.

Daniela Cimini

Open access · greenAbstract readReview
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Structure and function of the outer kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Total whole-arm chromosome losses predict malignancy in human cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Hansemann's anaplastic theory of cancer after 135 years.Frontiers in epigenetics and epigenomics · 2025
    Article
  8. Positioning centrioles and centrosomes.The Journal of cell biology · 2024
    Review
  9. The two sides of chromosomal instability: drivers and brakes in cancer.Signal transduction and targeted therapy · 2024
    Review
  10. Two decades of chromosomal instability and aneuploidy.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniela CiminiDepartment of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, 24061, USA. cimini@vt.edu.
Virginia Tech · US

Funding

Combining modeling and experiments to study the evolution of cells with altered ploidyR01GM140042 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CIMINI, DANIELA, SCHMELZ, EVA M. · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM140042NIH HHS R01GM140042
6 · The paper itself

Abstract

Micronuclei, small DNA-containing structures separate from the main nucleus, were used for decades as an indicator of genotoxic damage. Micronuclei containing whole chromosomes were considered a biomarker of aneuploidy and were believed to form, upon mitotic exit, from chromosomes that lagged behind in anaphase as all other chromosomes segregated to the poles of the mitotic spindle. However, the mechanism responsible for inducing anaphase lagging chromosomes remained unknown until just over twenty years ago. Here, I summarize what preceded and what followed this discovery, highlighting some of the open questions and opportunities for future investigation.

Indexed as

KinetochoresMitosisAneuploidyChromosome SegregationHumansMicrotubulesSpindle Apparatuschromosome segregationlagging chromosomemerotelicmicronucleimitosis

Identifiers

PMID37466740
PMCPMC10411636
OpenAlexW4384664128

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.