Evidence map›Paper›PMID 37469404›Full record

ArticleFrontiers in oncology2023

Mitochondrial apoptosis-related gene polymorphisms are associated with responses to anthracycline-based chemotherapy in acute myeloid leukaemia.

Guangqiang Meng, Mingying Li, Yuan Xia, Yuyan Wu, Yuechan Ma, Min Ji, Jingru Zhang, Jingjing Ye, Tao Sun, Chunyan Ji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Guangqiang MengDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Mingying LiDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Yuan XiaDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Yuyan WuDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Yuechan MaDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Min JiDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Jingru ZhangDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Jingjing YeDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Tao SunDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Chunyan JiDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although anthracyclines are the first-line chemotherapy drugs for treating non-M3 acute myeloid leukaemia (AML), their efficacy remains limited. It is important to identify factors that influence the efficacy of anthracyclines against AML. Mitochondrial apoptosis-related genes play significant roles in the pathogenesis, treatment, and prognosis of AML. Methods: We utilized the CRISPR/Cas9 screening system to find AML anthracyclines resistance related genes and several mitochondrial apoptosis-related genes, such as Results: Our findings indicated that SNP rs4251864 in the Conclusions: Our results about the association of SNPs in mitochondrial apoptosis-related genes with the response to anthracycline-based chemotherapy in AML provide an important reference for predicting the treatment outcomes in patients with this disease.

Indexed as

acute myeloid leukemiaanthracyclinesCRISPR/Cas9mitochondrial apoptosissingle nucleotide polymorphisms

Identifiers

PMID37469404
PMCPMC10352653
OpenAlexW4384820471

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.