Evidence map›Paper›PMID 37470322›Full record

ArticleThe Journal of physiology2023

Resistance training diminishes mitochondrial adaptations to subsequent endurance training in healthy untrained men.

Paulo H C Mesquita, Joshua S Godwin, Bradley A Ruple, Casey L Sexton, Mason C McIntosh, Breanna J Mueller, Shelby C Osburn, C Brooks Mobley, Cleiton A Libardi, Kaelin C Young and 3 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Paulo H C MesquitaSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Joshua S GodwinSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Bradley A RupleSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Casey L SextonSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Mason C McIntoshSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Breanna J MuellerSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Shelby C OsburnSchool of Kinesiology, Auburn University, Auburn, AL, USA.
C Brooks MobleySchool of Kinesiology, Auburn University, Auburn, AL, USA.
Cleiton A LibardiDepartment of Physical Education, Federal University of São Carlos, São Carlos, Brazil.ORCID 0000-0002-9003-7610
Kaelin C YoungBiomedical Sciences, Pacific Northwest University of Health Sciences, Yakima, WA, USA.
L Bruce GladdenSchool of Kinesiology, Auburn University, Auburn, AL, USA.ORCID 0000-0001-5193-7440
Michael D RobertsSchool of Kinesiology, Auburn University, Auburn, AL, USA.ORCID 0000-0002-7359-5362
Andreas N KavazisSchool of Kinesiology, Auburn University, Auburn, AL, USA.ORCID 0000-0002-2535-7490
Auburn University · USPacific Northwest University of Health Sciences · USUniversidade Federal de São Carlos · BR

Funding

G-RISE at Auburn UniversityT32GM141739 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI CLAYTON, TAFFYE BENSON, RUSSELL, MELODY L · 2021 to 2024
$1.2M
NIGMS NIH HHS T32 GM141739NIH HHS T32GM141739
6 · The paper itself

Abstract

We investigated the effects of performing a period of resistance training (RT) on the performance and molecular adaptations to a subsequent period of endurance training (ET). Twenty-five young adults were divided into an RT+ET group (n = 13), which underwent 7 weeks of RT followed by 7 weeks of ET, and an ET-only group (n = 12), which performed 7 weeks of ET. Body composition, endurance performance and muscle biopsies were collected before RT (T1, baseline for RT+ET), before ET (T2, after RT for RT+ET and baseline for ET) and after ET (T3). Immunohistochemistry was performed to determine fibre cross-sectional area (fCSA), myonuclear content, myonuclear domain size, satellite cell number and mitochondrial content. Western blots were used to quantify markers of mitochondrial remodelling. Citrate synthase activity and markers of ribosome content were also investigated. RT improved body composition and strength, increased vastus lateralis thickness, mixed and type II fCSA, myonuclear number, markers of ribosome content, and satellite cell content (P < 0.050). In response to ET, both groups similarly decreased body fat percentage (P < 0.0001) and improved endurance performance (e.g.

Indexed as

Endurance TrainingResistance TrainingAcclimatizationAdaptation, PhysiologicalBody CompositionHumansMaleMuscle, SkeletalYoung Adultaerobic trainingHIITmitochondrial remodellingskeletal musclestrength training

Identifiers

PMID37470322
PMCPMC11062412
OpenAlexW4384820336

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.