Evidence map›Paper›PMID 37473540›Full record

ArticleSocial science & medicine (1982)2023

Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain.

Pamela Jackson, Antoinette L Spector, Larissa J Strath, Lisa H Antoine, Peng Li, Burel R Goodin, Bertha A Hidalgo, Mirjam-Colette Kempf, Cesar E Gonzalez, Alana C Jones and 7 more

Abstract read
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In one paragraph

Article in Social science & medicine (1982), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pamela JacksonSchool of Public Health, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: jacksop2@uab.edu.
Antoinette L SpectorSchool of Rehabilitation Sciences and Technology, University of Wisconsin-Milwaukee, PO Box 413, Milwaukee, WI, 53201, USA; Pain Research and Intervention Center of Excellence (PRICE), University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA. Electronic address: aspector@uwm.edu.
Larissa J StrathDepartment of Community Dentistry and Behavioral Science, University of Florida, 1329 16th Street Southwest, Gainesville, FL, 32608, USA; Pain Research and Intervention Center of Excellence (PRICE), University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA. Electronic address: lstrath@dental.ufl.edu.
Lisa H AntoineDepartment of Psychology, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: antoinel@uab.edu.
Peng LiSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: pli@uab.edu.
Burel R GoodinWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, USA. Electronic address: burel@wustl.edu.
Bertha A HidalgoSchool of Public Health, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: bhidalgo@uab.edu.
Mirjam-Colette KempfSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: mkempf@uab.edu.
Cesar E GonzalezDepartment of Psychology, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: cesarg@uab.edu.
Alana C JonesSchool of Public Health, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: acjones@uab.edu.
Thomas C FosterDepartment of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL, 32610, USA. Electronic address: foster1@ufl.edu.
Jessica A PetersonPain Research and Intervention Center of Excellence (PRICE), University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA. Electronic address: jpeterson@dental.ufl.edu.
Tammie QuinnDepartment of Psychology, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: tquinn@uab.edu.
Zhiguang HuoDepartment of Biostatistics, University of Florida, 2004 Mowry Road, Gainesville, FL, 32603, USA. Electronic address: zhuo@ufl.edu.
Roger FillingimDepartment of Community Dentistry and Behavioral Science, University of Florida, 1329 16th Street Southwest, Gainesville, FL, 32608, USA; Pain Research and Intervention Center of Excellence (PRICE), University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA. Electronic address: rfillingim@dental.ufl.edu.
Yenisel Cruz-AlmeidaDepartment of Community Dentistry and Behavioral Science, University of Florida, 1329 16th Street Southwest, Gainesville, FL, 32608, USA; Pain Research and Intervention Center of Excellence (PRICE), University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA; Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL, 32610, USA. Electronic address: cryeni@ufl.edu.
Edwin N ArokeSchool of Nursing, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. Electronic address: earoke@uab.edu.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Ethnic Differences in Responses to Painful StimuliR37AG033906 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2014 to 2023
$12.9M
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain TissueR01AG067757 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2020 to 2024
$4.2M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back PainR01AR079178 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AROKE, EDWIN NGOMUEH · 2021 to 2024
$1.6M
Epigenetic Age Acceleration Impacts Racial and Neighborhood Disparities in Chronic Low Back PainR36AG077084 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JACKSON, PAMELA · 2022 to 2022
$49k
NIAMS NIH HHS R01 AR079178NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG059809NIA NIH HHS R01 AG067757NIA NIH HHS R36 AG077084NIA NIH HHS R37 AG033906
6 · The paper itself

Abstract

An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older adults having greater risk. Like other age-related diseases, residents of high-deprivation neighborhoods experience worse KOA pain outcomes compared to their more affluent neighbors. The purpose of this study was to examine the relationship between neighborhood deprivation and pain severity in KOA and the influence of epigenetic age acceleration (EpAA) on that relationship. The sample of 128 participants was mostly female (60.9%), approximately half non-Hispanic Black (49.2%), and had a mean age of 58 years. Spearman bivariate correlations revealed that pain severity positively correlated with EpAA (ρ = 0.47, p ≤ 0.001) and neighborhood deprivation (ρ = 0.25, p = 0.004). We found a positive significant relationship between neighborhood deprivation and EpAA (ρ = 0.47, p ≤ 0.001). Results indicate a mediating relationship between neighborhood deprivation (predictor), EpAA (mediator), and pain severity (outcome variable). There was a significant indirect effect of neighborhood deprivation on pain severity through EpAA, as the mediator accounted for a moderate portion of the total effect, PM = 0.44. Epigenetic age acceleration may act as a mechanism through which neighborhood deprivation leads to worse KOA pain outcomes and may play a role in the well-documented relationship between the neighborhood of residence and age-related diseases.

Indexed as

Osteoarthritis, KneeAgedEpigenesis, GeneticFemaleHumansKnee JointMaleMiddle AgedPainPain MeasurementResidence CharacteristicsAge-related conditionsEpigenetic agingNeighborhood deprivationPain disparities

Identifiers

PMID37473540
PMCPMC10407756

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.