Evidence map›Paper›PMID 37474111›Full record

ArticleEuropean journal of endocrinology2023

Oxytocin response to food intake in avoidant/restrictive food intake disorder.

Anna Aulinas, Maged Muhammed, Kendra R Becker, Elisa Asanza, Kristine Hauser, Casey Stern, Julia Gydus, Tara Holmes, Helen Burton Murray, Lauren Breithaupt and 5 more

Open access · greenAbstract read
In one paragraph

Article in European journal of endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Anna AulinasDepartment of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0002-1205-7114
Maged MuhammedNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.
Kendra R BeckerDepartment of Medicine, Harvard Medical School, 02115 Boston, MA, United States.
Elisa AsanzaNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.
Kristine HauserNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.ORCID 0000-0001-7317-5440
Casey SternNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.
Julia GydusNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.
Tara HolmesTranslational and Clinical Research Center, Massachusetts General Hospital, 02114 Boston, MA, United States.
Helen Burton MurrayDepartment of Medicine, Harvard Medical School, 02115 Boston, MA, United States.
Lauren BreithauptDepartment of Medicine, Harvard Medical School, 02115 Boston, MA, United States.
Nadia MicaliEating Disorders Research Unit, Mental Health Services of the Capital Region of Denmark, Psychiatric Centre Ballerup, 2750 Ballerup, Denmark.
Madhusmita MisraNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.ORCID 0000-0002-9405-2981
Kamryn T EddyDepartment of Medicine, Harvard Medical School, 02115 Boston, MA, United States.
Jennifer J ThomasDepartment of Medicine, Harvard Medical School, 02115 Boston, MA, United States.
Elizabeth A LawsonNeuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, 02114 Boston, MA, United States.
Harvard University · USMassachusetts General Hospital · USGreat Ormond Street Hospital · GBUniversitat de Vic - Universitat Central de Catalunya · ES

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
TRAINING GRANT IN ACADEMIC ENDOCRINOLOGYT32DK007529 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser, Anand Vaidya · 1986 to 2026
$6.3M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative EmotionsK23MH125143 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2021 to 2025
$1.1M
Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
Reward Processing in Anorexia Nervosa and Avoidant/Restrictive Food Intake Disorder: Behavior, Hormonal Concentrations, and Brain Activation in Low-Weight Eating Disorders.F32MH111127 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2016 to 2018
$185k
NCATS NIH HHS UL1 TR002541NIDDK NIH HHS K23 DK131334NIDDK NIH HHS P30 DK040561NIDDK NIH HHS T32 DK007529NIH HHSNIMH NIH HHS F32 MH111127NIMH NIH HHS K23 MH125143NIMH NIH HHS K24 MH120568NIMH NIH HHS R01 MH103402NIMH NIH HHS R01 MH108595
6 · The paper itself

Abstract

objectiveTo investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in food or eating, sensory sensitivity to food, and/or fear of aversive consequences of eating, compared with healthy controls (HC).

designCross-sectional.

methodsA total of 109 participants (54 with ARFID spectrum and 55 HC) were instructed to eat a ∼400-kcal standardized mixed meal. We sampled serum oxytocin at fasting and at 30-, 60-, and 120-min postmeal. We tested the hypothesis that ARFID would show higher mean oxytocin levels across time points compared with HC using a mixed model ANOVA. We then used multivariate regression analysis to identify the impact of clinical characteristics (sex, age, and body mass index [BMI] percentile) on oxytocin levels in individuals with ARFID.

resultsParticipants with ARFID exhibited greater mean oxytocin levels at all time points compared with HC, and these differences remained significant even after controlling for sex and BMI percentile (P = .004). Clinical variables (sex, age, and BMI percentile) did not show any impact on fasting and postprandial oxytocin levels among individuals with ARFID.

conclusionsConsistently high oxytocin levels might be involved in low appetite and sensory aversions to food, contributing to food avoidance in individuals with ARFID.

Indexed as

Avoidant Restrictive Food Intake DisorderFeeding and Eating DisordersAdolescentCross-Sectional StudiesEatingHumansOxytocinRetrospective StudiesYoung AdultOxytocinavoidant/restrictive food intake disorderfeeding and eating disordersfood controlhypothalamusoxytocin

Identifiers

PMID37474111
PMCPMC10396082
OpenAlexW4384925366

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.