Evidence map›Paper›PMID 37479751›Full record

ArticleScientific reports2023

Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model.

Marcos David Munoz, Alexa Zamudio, Maximilian McCann, Victoria Gil, Pingwen Xu, Chong Wee Liew

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marcos David MunozDepartment of Physiology and Biophysics, The University of Illinois at Chicago, 909 S Wolcott Ave, RM 2099, Chicago, IL, 60612, USA.
Alexa ZamudioDepartment of Physiology and Biophysics, The University of Illinois at Chicago, 909 S Wolcott Ave, RM 2099, Chicago, IL, 60612, USA.
Maximilian McCannDepartment of Physiology and Biophysics, The University of Illinois at Chicago, 909 S Wolcott Ave, RM 2099, Chicago, IL, 60612, USA.
Victoria GilDepartment of Physiology and Biophysics, The University of Illinois at Chicago, 909 S Wolcott Ave, RM 2099, Chicago, IL, 60612, USA.
Pingwen XuDepartment of Physiology and Biophysics, The University of Illinois at Chicago, 909 S Wolcott Ave, RM 2099, Chicago, IL, 60612, USA.
Chong Wee LiewDepartment of Physiology and Biophysics, The University of Illinois at Chicago, 909 S Wolcott Ave, RM 2099, Chicago, IL, 60612, USA. cwliew@uic.edu.
University of Illinois Chicago · USUniversity of Chicago · US

Funding

TRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI GRAEME I BELL, Raghavendra G Mirmira · 2013 to 2026
$20.9M
Testosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasisR01DK123098 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2020 to 2024
$2.5M
EMC10, a novel obesity-regulated circulating factor, regulates energy and metabolic homeostasisR01DK109015 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2016 to 2020
$1.8M
Role of the transcriptional coregulator, TRIP Br2, in adipocyte metabolismR00DK090210 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2012 to 2014
$724k
NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P60 DK020595NIDDK NIH HHS R00 DK090210NIDDK NIH HHS R01 DK109015NIDDK NIH HHS R01 DK123098
6 · The paper itself

Abstract

Long-term ad libitum dietary restrictions, such as low-protein diets (LPDs), improve metabolic health and extend the life span of mice and humans. However, most studies conducted thus far have focused on the preventive effects of LPDs on metabolic syndromes. To test the therapeutic potential of LPD, we treated a lipodystrophy mouse model IR

Indexed as

Diabetes MellitusHyperglycemiaInsulin ResistanceLipodystrophyAdipose Tissue, BrownAnimalsDiet, Protein-RestrictedDisease Models, AnimalGlucoseHumansGlucose

Identifiers

PMID37479751
PMCPMC10362023
OpenAlexW4385064691

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.