Evidence map›Paper›PMID 37480458›Full record

ReviewAdvances in neurobiology2023

Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer's Disease Brain Pathology Exacerbated by Sleep Deprivation.

Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 6 countries.

Aruna SharmaInternational Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Lianyuan FengDepartment of Neurology, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.
Dafin F MuresanuDepartment Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania.
Z Ryan TianDepartment Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, USA.
José Vicente LafuenteLaNCE, Department Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.
Anca D BuzoianuDepartment of Clinical Pharmacology and Toxicology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Ala NozariAnesthesiology & Intensive Care, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Igor BryukhovetskiyDepartment of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Igor ManzhuloLaboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.
Lars WiklundInternational Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Hari Shanker SharmaInternational Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Sharma@surgsci.uu.se.
Uppsala University Hospital · SEA.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences · RUBethune International Peace Hospital · CNBoston University · USIuliu Hațieganu University of Medicine and Pharmacy · ROResearch Institute for Analytical Instrumentation · ROUniversity of Arkansas at Fayetteville · USUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep deprivation induces amyloid beta peptide and phosphorylated tau deposits in the brain and cerebrospinal fluid together with altered serotonin metabolism. Thus, it is likely that sleep deprivation is one of the predisposing factors in precipitating Alzheimer's disease (AD) brain pathology. Our previous studies indicate significant brain pathology following sleep deprivation or AD. Keeping these views in consideration in this review, nanodelivery of monoclonal antibodies to amyloid beta peptide (AβP), phosphorylated tau (p-tau), and tumor necrosis factor alpha (TNF-α) in sleep deprivation-induced AD is discussed based on our own investigations. Our results suggest that nanowired delivery of monoclonal antibodies to AβP with p-tau and TNF-α induces superior neuroprotection in AD caused by sleep deprivation, not reported earlier.

Indexed as

Alzheimer DiseaseAmino AcidsAmyloid beta-PeptidesAntibodies, MonoclonalBrainHumansNanoparticle Drug Delivery SystemNeuroprotectionSleep Deprivationtau ProteinsTumor Necrosis Factor-alphaAmino AcidsAmyloid beta-PeptidesAntibodies, MonoclonalcerebrolysinNanoparticle Drug Delivery Systemtau ProteinsTumor Necrosis Factor-alphaAlzheimer’s diseaseBrain pathologyMonoclonal antibodiesNanomedicine amyloid beta peptideNanowired deliveryNeuroprotectionPhosphorylated p-tauSerotonin6 receptor antagonistSleep deprivation

Identifiers

PMID37480458
OpenAlexW4385146071

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.