Evidence map›Paper›PMID 37480461›Full record

ReviewAdvances in neurobiology2023

Neuroprotective Effects of Nanowired Delivery of Cerebrolysin with Mesenchymal Stem Cells and Monoclonal Antibodies to Neuronal Nitric Oxide Synthase in Brain Pathology Following Alzheimer's Disease Exacerbated by Concussive Head Injury.

Hari Shanker Sharma, Dafin F Muresanu, Ala Nozari, José Vicente Lafuente, Anca D Buzoianu, Z Ryan Tian, Hongyun Huang, Lianyuan Feng, Igor Bryukhovetskiy, Igor Manzhulo and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 6 countries.

Hari Shanker SharmaInternational Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Sharma@surgsci.uu.se.
Dafin F MuresanuDepartment of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania.
Ala NozariAnesthesiology & Intensive Care, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
José Vicente LafuenteLaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.
Anca D BuzoianuDepartment of Clinical Pharmacology and Toxicology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Z Ryan TianDepartment of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Hongyun HuangBeijing Hongtianji Neuroscience Academy, Beijing, China.
Lianyuan FengDepartment of Neurology, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.
Igor BryukhovetskiyDepartment of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Igor ManzhuloLaboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.
Lars WiklundInternational Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Aruna SharmaInternational Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Uppsala University Hospital · SEA.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences · RUBethune International Peace Hospital · CNBoston University · USFar Eastern Federal University · RUIuliu Hațieganu University of Medicine and Pharmacy · ROResearch Institute for Analytical Instrumentation · ROUniversity of Arkansas at Fayetteville · USUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concussive head injury (CHI) is one of the major risk factors in developing Alzheimer's disease (AD) in military personnel at later stages of life. Breakdown of the blood-brain barrier (BBB) in CHI leads to extravasation of plasma amyloid beta protein (ΑβP) into the brain fluid compartments precipitating AD brain pathology. Oxidative stress in CHI or AD is likely to enhance production of nitric oxide indicating a role of its synthesizing enzyme neuronal nitric oxide synthase (NOS) in brain pathology. Thus, exploration of the novel roles of nanomedicine in AD or CHI reducing NOS upregulation for neuroprotection are emerging. Recent research shows that stem cells and neurotrophic factors play key roles in CHI-induced aggravation of AD brain pathologies. Previous studies in our laboratory demonstrated that CHI exacerbates AD brain pathology in model experiments. Accordingly, it is quite likely that nanodelivery of NOS antibodies together with cerebrolysin and mesenchymal stem cells (MSCs) will induce superior neuroprotection in AD associated with CHI. In this review, co-administration of TiO

Indexed as

Alzheimer DiseaseCraniocerebral TraumaMesenchymal Stem CellsNeuroprotective AgentsAmino AcidsAmyloid beta-PeptidesAntibodies, MonoclonalBrainHumansNerve Growth FactorsNitric Oxide Synthase Type IAmino AcidsAmyloid beta-PeptidesAntibodies, MonoclonalcerebrolysinNerve Growth FactorsNeuroprotective AgentsNitric Oxide Synthase Type IAlzheimer’s diseaseBrain edemaBrain pathologyCerebrolysinMesenchymal stem cellsNanomedicine blood–brain barrierNanowired deliveryNitric oxide synthase-neuroprotectionOxidative stressTraumatic brain injury

Identifiers

PMID37480461
OpenAlexW4385151339

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.