Evidence map›Paper›PMID 37482124›Full record

ArticleJournal of pharmaceutical sciences2023

PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model.

Sanaalarab Al Enazy, Gregory W Kirschen, Kathleen Vincent, Jinping Yang, Jamal Saada, Mansi Shah, Andres F Oberhauser, Paul J Bujalowski, Massoud Motamedi, Salama A Salama and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Simvastatin-loaded liposomal nanoparticles as treatment for adenomyosis in a patient-derived xenograft mouse model: a pilot study.Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2025
    Article
  3. [Protective effects of 2-methoxyestradiol against hypoxic pulmonary hypertension in neonatal rats].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  4. The Role of Nanomedicine in Benign Gynecologic Disorders.Molecules (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sanaalarab Al EnazyDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gregory W KirschenDepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD, USA.
Kathleen VincentCenter for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX, USA; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Jinping YangCenter for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX, USA.
Jamal SaadaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Mansi ShahDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Andres F OberhauserDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Paul J BujalowskiDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Massoud MotamediCenter for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX, USA.
Salama A SalamaDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Gokhan KilicDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Erik RyttingDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, USA; Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX, USA; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Mostafa A BorahayDepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD, USA. Electronic address: mboraha1@jhmi.edu.
The University of Texas Medical Branch at Galveston · USJohns Hopkins University · USAl-Azhar University · EGThe University of Texas MD Anderson Cancer Center · US

Funding

Role of senescent cells in uterine fibroid pathogenesisR01HD111243 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$792k
UTMB Women's Health Research Scholar's ProgramK12HD052023 · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · 2005 to 2005
$500k
NICHD NIH HHS K12 HD052023NICHD NIH HHS R01 HD094380NICHD NIH HHS R01 HD111243
6 · The paper itself

Abstract

Leiomyomas, the most common benign neoplasms of the female reproductive tract, currently have limited medical treatment options. Drugs targeting estrogen/progesterone signaling are used, but side effects and limited efficacy in many cases are major limitation of their clinical use. Previous studies from our laboratory and others demonstrated that 2-methoxyestradiol (2-ME) is promising treatment for uterine fibroids. However, its poor bioavailability and rapid degradation hinder its development for clinical use. The objective of this study is to evaluate the in vivo effect of biodegradable and biocompatible 2-ME-loaded polymeric nanoparticles in a patient-derived leiomyoma xenograft mouse model. PEGylated poly(lactide-co-glycolide) (PEG-PLGA) nanoparticles loaded with 2-ME were prepared by nanoprecipitation. Female 6-week age immunodeficient NOG (NOD/Shi-scid/IL-2Rγ

Indexed as

LeiomyomaNanoparticles2-MethoxyestradiolAnimalsEstrogensFemaleHeterograftsHumansMercaptoethanolMiceMice, Inbred NODPolyethylene GlycolsPolymersProgesterone2-MethoxyestradiolEstrogensMercaptoethanolPolyethylene GlycolsPolymersProgesteroneBioavailabilityDrug delivery systemEstrogenFibroidNanoparticlesPrecision medicine

Identifiers

PMID37482124
PMCPMC10529399
OpenAlexW4384945654

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.