ArticleHeliyon2023
Evaluation of the pulp response following direct pulp capping with exogenous nitric oxide and Mineral Trioxide Aggregate (MTA) a histologic study.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Histopathologic responses of the dental pulp to an experimental calcium aluminate-calcium silicate based capping material in comparison to mineral trioxide aggregate.Scientific reports · 2026Article
- In Vivo Comparison of Resin-Modified and Pure Calcium-Silicate Cements for Direct Pulp Capping.Applied sciences (Basel, Switzerland) · 2025Article
- Pulp response following direct pulp capping with Tideglusib and mineral trioxide aggregate: an animal study.BMC oral health · 2025Article
- Comparative Evaluation of Three Calcium Silicate-Based Materials for Direct Pulp Capping: AnbioRxiv : the preprint server for biology · 2025Article
- Physiologic dentin regeneration: its past, present, and future perspectives.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recently, vital pulp therapy is widely used all over the world. It aims to maintain the viability and function of the injured dental pulp tissue. Direct pulp capping is recognized as one of the most common used techniques in this approach. Aim of the study: we aimed to compare the histopathological response of the dental pulp following direct pulp capping using two different capping materials; the exogenous nitric oxide (NOC-18) and Mineral Trioxide Aggregate (MTA) in dogs' teeth. Methods and materials: The pulp of thirty-two premolars and canines from four dogs (eight teeth per each dog) the pulp was exposed and treated with either exogenous nitric oxide (NOC-18) and MTA (four teeth in each group). The treated teeth were extracted and prepared for histologic evaluation after one month and three months, respectively. The histologic study evaluated the formation of dentine bridge, the degree of pulpitis, calcification of the coronal pulp tissue and odontoblasts layer activity. We have the ethical approval to achieve this research from the scientific committee in Faculty of Dentistry, Damascus University. Results: The results showed that the active statue of odontoblasts layer in NOC-18 group was significantly more than in MTA group after a month of recall ( Conclusion: Exogenous nitric oxide (NOC-18) maybe has a positive impact on formation of calcified bridge and efficacy of odontoblasts layer on directly capped dog's teeth. Exogenous NO donors might offer alternative to current pulp capping agents in Vital Pulp Therapy in endodontic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.