Evidence map›Paper›PMID 37484033›Full record

ArticlePaediatrics & child health2023

Precision oncology for children: A primer for paediatricians.

Sarah Cohen-Gogo, Avram E Denburg, Anita Villani, Nirav Thacker, Grace Egan, Margarida Simao Rafael, David Malkin, Daniel A Morgenstern

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatrics & child health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sarah Cohen-GogoDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-8852-1104
Avram E DenburgDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Anita VillaniDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nirav ThackerDivision of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Grace EganDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Margarida Simao RafaelDepartment of Oncology, Solid Tumor Section, Hospital Sant Joan de Déu, Barcelona, Spain.
David MalkinDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Daniel A MorgensternDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
University of Toronto · CAHospital for Sick Children · CAChildren's Hospital of Eastern Ontario · CAHospital Sant Joan de Déu Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is the leading cause of disease-related death in children, adolescents, and young adults beyond the newborn period in North America. Improving survival rates for patients with hard-to-cure cancer remains a challenge. One approach that has gained particular traction is 'precision oncology', whereby next-generation sequencing is used to identify genomic or transcriptomic changes that can help clarify the diagnosis, refine prognosis, define an underlying genetic cause, or identify a unique treatment target for a patient's cancer. In this primer, we provide a brief overview of the evolution of precision paediatric oncology, its current application to clinical oncology practice, and its future potential as a foundational approach to paediatric oncology care in Canada and around the world. We also address the many challenges and limitations inherent to the implementation of precision oncology as the standard of care, including ethical and economic considerations.

Indexed as

CancerCancer predispositionMolecular tumour boardNext-generation sequencingPrecision medicineTargeted therapy

Identifiers

PMID37484033
PMCPMC10362955
OpenAlexW4328052140

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.