ArticleFrontiers in cardiovascular medicine2023
Systemic immune-inflammation index is associated with coronary heart disease: a cross-sectional study of NHANES 2009-2018.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systemic immune-inflammation index as a novel predictor of major adverse cardiovascular events in patients undergoing percutaneous coronary intervention: a meta-analysis of cohort studies.BMC cardiovascular disorders · 2024Pooled it
- The systemic immune-inflammation index in coronary heart disease: a narrative review of thromboinflammation, phenotype-dependent utility, and clinical translation.Frontiers in cardiovascular medicine · 2026Review
- The Systemic Immune-Inflammation Index and High-Sensitivity C-Reactive Protein to High-Density Lipoprotein Cholesterol Ratio Predict Moderate and Severe Coronary Artery Stenosis in Older Patients with Coronary Heart Disease.Clinical interventions in aging · 2026Article
- Periodontitis and Systemic Disease: The Impact of Covariate Selection.Journal of dental research · 2026Article
- Associations of Inflammatory Markers and Coronary Heart Disease in Different Gender Groups in Cohort NHANES 2003-2018.Cardiology research and practice · 2026Article
- Evaluation of nosocomial infections after congenital heart surgery in children: a comprehensive analysis including the systemic immune-inflammation index.Frontiers in pediatrics · 2026Article
- Essential and Toxic Elements in Cardiovascular Disease: Pathophysiological Roles and the Emerging Contribution of Hair Mineral Analysis.International journal of molecular sciences · 2025Review
- Oral and Periodontal Health Status, Peripheral Immune Dysregulation, and Cognitive Impairment in Alzheimer's Disease: A Clinical and Immunological Study.International journal of molecular sciences · 2025Article
- Comparison of systemic inflammatory markers in total knee arthroplasty under spinal vs general anesthesia: a retrospective study.BMC anesthesiology · 2025Article
- The association between systemic immune-inflammatory index and cardiac biomarkers among US population: a cross-sectional study.European journal of medical research · 2025Article
- Effects of statins on major adverse cardiovascular events, metabolic and inflammatory parameters in patients with hepatitis B virus comorbid with cardiovascular disease.Cardiovascular diagnosis and therapy · 2025Article
- Effect of puerarin administration on serum NOD-like receptor protein 3 (NLRP3) inflammasome, C1Q/TNF-related protein 3 (CTRP3) and lipoprotein-associated phospholipase 2 (LP-PLA2) levels.Journal of medical biochemistry · 2025Article
- An Exploratory Study of Inflammatory Biomarkers and Extrapyramidal Side Effects in Patients with Schizophrenia.Schizophrenia bulletin open · 2025Article
- Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States.Journal of inflammation research · 2025Article
- Association between SII and postoperative pulmonary infection in elderly patients undergoing laparoscopic abdominal surgery.Frontiers in medicine · 2025Article
- TyG index and CBC-derived inflammatory indicators individual and mixed effects on all-cause and cardiovascular disease deaths in patients with CHD.Frontiers in cardiovascular medicine · 2025Article
- Sleep Patterns and Cardiovascular Disease Risk: Investigating the Mediating Role of Inflammatory Markers in a Large NHANES Adult Population.Mediators of inflammation · 2025Article
- Neutrophil-lymphocyte ratio and systemic immune-inflammation index as predictors of cardiovascular risk and mortality in prediabetes and diabetes: a population-based study.Inflammopharmacology · 2024Article
- Association Between Systemic Immune Inflammation Index and Diabetes Mellitus in the NHANES 2003-2018 Population.Journal of the Endocrine Society · 2024Article
- Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999-2018.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammation has been linked to the development of coronary heart disease (CHD). The systemic immune inflammation index (SII) is a useful biomarker of systemic inflammation. Our study aimed to explore the correlation between SII and CHD. Methods: We conducted a multivariate logistic regression analysis, smoothing curve fitting, and segmented model comparison on 15,905 participants with a CHD prevalence of 3.31% and a mean age of 46.97 years. Results: Adjusting for gender, age, and race, we found a negative association between SII and CHD [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.48, 0.90]. There was an inverse trend where increasing SII was associated with decreasing odds of CHD ( Conclusions: Our findings suggest that higher SII values may be associated with a higher incidence of CHD, which varies by gender. SII may be a cost-effective and convenient method to detect CHD. Further studies are needed to confirm the causality of these findings in a larger prospective cohort.
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Registered trials
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