Evidence map›Paper›PMID 37487639›Full record

ArticleLife science alliance2023

Catalytic mechanism of the zinc-dependent MutL endonuclease reaction.

Kenji Fukui, Tatsuya Yamamoto, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kenji FukuiDepartment of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan kenji.fukui@ompu.ac.jp.ORCID https://orcid.org/0000-0003-2463-7578
Tatsuya YamamotoBioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.ORCID https://orcid.org/0000-0001-8356-8248
Takeshi MurakawaDepartment of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Seiki BabaStructural Biology Division, Japan Synchrotron Radiation Research Institute (JASRI), Hyogo, Japan.
Takashi KumasakaStructural Biology Division, Japan Synchrotron Radiation Research Institute (JASRI), Hyogo, Japan.ORCID https://orcid.org/0000-0001-9289-1557
Takato YanoDepartment of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan takato.yano@ompu.ac.jp.ORCID https://orcid.org/0000-0002-9720-8339
Osaka University of Pharmaceutical Sciences · JPJapan Synchrotron Radiation Research Institute · JPSuntory Foundation for Life Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA mismatch repair endonuclease MutL binds two zinc ions. However, the endonuclease activity of MutL is drastically enhanced by other divalent metals such as manganese, implying that MutL binds another catalytic metal at some site other than the zinc-binding sites. Here, we solved the crystal structure of the endonuclease domain of

Indexed as

CadmiumZincCatalysisEndonucleasesManganeseCadmiumEndonucleasesManganeseZinc

Identifiers

PMID37487639
PMCPMC10366529
OpenAlexW4385214721

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.