ArticleeLife2023
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Role of the CDKL1-SOX11 signaling axis in acute kidney injury.American journal of physiology. Renal physiology · 2024Article
- Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.ACS medicinal chemistry letters · 2024Article
- Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder.Molecular autism · 2024Article
- Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain.Molecular psychiatry · 2024Article
- Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.bioRxiv : the preprint server for biology · 2024Article
- Quantification of Binding of Small Molecules to Native Proteins Overexpressed in Living Cells.Journal of the American Chemical Society · 2024Article
- Illumination of understudied ciliary kinases.Frontiers in molecular biosciences · 2024Review
- Review
- Genome-Wide Exploration and Expression Analysis of the CNGC Gene Family in Eggplant (International journal of molecular sciences · 2023Article
- Article
Corrections and comments
- Update of
Authors and funding
19 authors at 5 institutions in 3 countries.
Anna Castano *Department of Pharmacology, University of Colorado School of Medicine, Aurora, United States.
Margaux Silvestre *Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0003-1377-477X
Carrow I WellsStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID https://orcid.org/0000-0003-4799-6792
Jennifer L SandersonDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, United States.
Carla A FerrerStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Han Wee OngStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Yi LangStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
William RichardsonCentre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Josie A SilvaroliDivision of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, United States.
Frances M BashoreStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID https://orcid.org/0000-0003-4241-9873
Jeffery L SmithStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID https://orcid.org/0000-0003-2189-0420
Isabelle M GenereuxStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Kelvin DempsterKinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0009-0009-0750-0175
David H DrewryStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Navlot S PablaDivision of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, United States.ORCID https://orcid.org/0000-0001-9408-0539
Alex N BullockCentre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Tim A BenkeDepartments of Pediatrics, Pharmacology, Neurology and Otolaryngology, University of Colorado School of Medicine, Aurora, United States.ORCID https://orcid.org/0000-0002-6969-5061
Sila K UltanirKinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0001-5745-3957
Alison D AxtmanStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
University of North Carolina at Chapel Hill · USThe Francis Crick Institute · GBUniversity of Colorado Denver · USDiscovery Centre · CAThe Ohio State University · US
Funding
Illuminating Function of the Understudied Druggable KinomeU24DK116204 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHNSON, GARY L. · 2017 to 2022
$13.6MTools for Accelerating R&D for Historically Understudied Protein KinasesR44TR001916 · NCATS · LUCEOME BIOTECHNOLOGIES, LLC · PI ZUTSHI, REENA · 2017 to 2018
$1.4MPilot studies to characterize CDKL5 inhibitorsR21NS112770 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BENKE, TIMOTHY A · 2020 to 2020
$444kCancer Research UK CC2037Medical Research Council CC2037NCATS NIH HHS R44 TR001916NIDDK NIH HHS U24 DK116204NIH HHS R44TR001916NIH HHS U24DK116204NINDS NIH HHS NS112770NINDS NIH HHS R21 NS112770Wellcome Trust CC2037
Abstract
Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (
Indexed as
HippocampusProtein Serine-Threonine KinasesAnimalsCyclin-Dependent KinasesEpileptic SyndromesGlycogen Synthase Kinase 3 betaHumansMiceMice, KnockoutSpasms, InfantileCDKL5 protein, humanCDKL5 protein, mouseCyclin-Dependent KinasesGlycogen Synthase Kinase 3 betaProtein Serine-Threonine KinasesCDKL5GSK3hippocampusLTPneuroscienceprotein kinaserat
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.