Evidence map›Paper›PMID 37490433›Full record

ArticlePLoS biology2023

NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes.

Yao Yao

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Gut microbes · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Yao YaoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America.ORCID 0000-0001-8020-9696
University of South Florida · US

Funding

Endothelial laminin in blood brain barrier regulationR01HL146574 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2019 to 2023
$1.9M
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationRF1AG065345 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$1.8M
Screening and identification of pericyte-specific and subpopulation-specific markersR21AG064422 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2020 to 2021
$415k
Cell-specific changes of laminin expression in the CNS in Alzheimer’s diseaseR21AG073862 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$411k
NHLBI NIH HHS R01 HL146574NIA NIH HHS R21 AG064422NIA NIH HHS R21 AG073862NIA NIH HHS RF1 AG065345
6 · The paper itself

Abstract

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.

Indexed as

MicrogliaStrokeGene Expression RegulationHumansNuclear Receptor Subfamily 4, Group A, Member 1RNA, MessengerTranscription FactorsNR4A1 protein, humanNuclear Receptor Subfamily 4, Group A, Member 1RNA, MessengerTranscription Factors

Identifiers

PMID37490433
PMCPMC10368268
OpenAlexW4385252098

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.