SynthesisNature communications2023
Overcoming attenuation bias in regressions using polygenic indices.
Synthesis in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Integrating common and rare variants improves polygenic risk prediction across diverse populations.Nature communications · 2026Article
- The Economics and Econometrics of Gene-Environment Interplay.The Review of economic studies · 2026Article
- Polygenic Risks for Mood Disorders and Economic Well-being: Study of Finnish Cohorts.Depression and anxiety · 2026Article
- Assessing Orthogonality in Gene-Environment Interaction Studies Using Polygenic Indices.Behavior genetics · 2026Article
- Genetic disparities in sleep traits and human capital development: A 25-year study in Finnish population-based cohorts.Scandinavian journal of work, environment & health · 2026Article
- An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference.Research square · 2025Article
- An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference.bioRxiv : the preprint server for biology · 2025Article
- Distinct genetic underpinnings of inter-individual differences in the sensorimotor-association axis of cortical organisation.bioRxiv : the preprint server for biology · 2025Article
- A Bayesian approach to correcting the attenuation bias of regression using polygenic risk score.Genetics · 2025Article
- An analysis of the accuracy of retrospective birth location recall using sibling data.Nature communications · 2024Article
- A Bayesian Approach to Correcting the Attenuation Bias of Regression Using Polygenic Risk Score.bioRxiv : the preprint server for biology · 2023Article
- The identification of mediating effects using genome-based restricted maximum likelihood estimation.PLoS genetics · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in regression models. We analyze and compare two approaches addressing this attenuation bias: Obviously Related Instrumental Variables (ORIV) and the PGI Repository Correction (PGI-RC). Through simulations, we show that the PGI-RC performs slightly better than ORIV, unless the prediction sample is very small (N < 1000) or when there is considerable assortative mating. Within families, ORIV is the best choice since the PGI-RC correction factor is generally not available. We verify the empirical validity of the simulations by predicting educational attainment and height in a sample of siblings from the UK Biobank. We show that applying ORIV between families increases the standardized effect of the PGI by 12% (height) and by 22% (educational attainment) compared to a meta-analysis-based PGI, yet estimates remain slightly below the PGI-RC estimates. Furthermore, within-family ORIV regression provides the tightest lower bound for the direct genetic effect, increasing the lower bound for the standardized direct genetic effect on educational attainment from 0.14 to 0.18 (+29%), and for height from 0.54 to 0.61 (+13%) compared to a meta-analysis-based PGI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.