Evidence map›Paper›PMID 37495507›Full record

ArticlePhysiological reports2023

Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes.

Luke A Howlett, Harley Stevenson-Cocks, Michael A Colman, Matthew K Lancaster, Alan P Benson

Abstract read
In one paragraph

Article in Physiological reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luke A HowlettFaculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID 0000-0002-7786-5569
Harley Stevenson-CocksFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Michael A ColmanFaculty of Biological Sciences, University of Leeds, Leeds, UK.
Matthew K LancasterFaculty of Biological Sciences, University of Leeds, Leeds, UK.
Alan P BensonFaculty of Biological Sciences, University of Leeds, Leeds, UK.

Funding

British Heart Foundation PG/16/74/32374Medical Research Council MR/V010050/1
6 · The paper itself

Abstract

This study aimed to simulate ventricular responses to elevations in myocyte pacing and adrenergic stimulation using a novel electrophysiological rat model and investigate ion channel responses underlying action potential (AP) modulations. Peak ion currents and AP repolarization to 50% and 90% of full repolarization (APD

Indexed as

Adrenergic AgentsMyocytes, CardiacAction PotentialsAnimalsHeart VentriclesPotassiumRatsAdrenergic AgentsPotassiumaction potentialcomputational modelingelectrophysiologyexerciseion currentsrepolarization

Identifiers

PMID37495507
PMCPMC10371833

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.