ArticleMolecular psychiatry2023
Circulating metabolites modulated by diet are associated with depression.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder.Lipids in health and disease · 2025Pooled it
- Investigating genetic links between blood metabolites and preeclampsia.BMC women's health · 2024Pooled it
- The causal relationship between serum metabolites and the risk of psoriasis: a Mendelian randomization and meta-analysis study.Frontiers in immunology · 2024Pooled it
- Gene-Environment Interaction Mendelian Randomization Reveals Statin-Dependent Associations Between Metabolites and Lipid Traits.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Psychological medicine · 2026Article
- Dynamic interactions between gut microbiome and host lipidome in antenatal depression: a large longitudinal study.Molecular psychiatry · 2026Article
- Article
- Decoding depression: stress-derived formaldehyde initiates depressive symptoms in mouse and human.Molecular psychiatry · 2026Article
- Gut microbial metabolic disorder in depression: insights from computational modeling and mediation analysis.BMC microbiology · 2026Article
- Association Between Metabolic Syndrome and Psychiatric Morbidity in a Nationwide Taiwanese Population Study.Nutrients · 2026Article
- Blood-Based Metabolomic Biomarkers and Personality Traits in Major Depressive Disorder: Toward an Integrated Framework for Precision Psychiatry.Advances in experimental medicine and biology · 2026Review
- Polyphenol intake and depressive symptoms in young adults: evidence from a population-based longitudinal study.The British journal of nutrition · 2025Article
- Association between methylmalonic acid and prevalence of depression in US adults: evidence from NHANES 2011-2014.European journal of psychotraumatology · 2025Article
- Metabolomic biomarkers predict long-term physical function in survivors of acute respiratory failure.Respiratory research · 2025Article
- Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice.Translational psychiatry · 2025Article
- Review
- Metabolomic Biomarkers Predict Long-term Physical Function in Survivors of Acute Respiratory Failure.Research square · 2025Article
- Mendelian randomization suggests a causal relationship between cerebrospinal fluid metabolites and intracranial aneurysms.Neurosurgical review · 2025Article
- The impact of the Social Exposome in Cardiovascular Health and Disease.Journal of precision medicine (Amsterdam, Netherlands) · 2025Article
- Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons.Translational psychiatry · 2025Article
Corrections and comments
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Authors and funding
37 authors at 13 institutions in 7 countries.
Funding
Abstract
Metabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex disease like major depression. To identify metabolites associated with depression we performed a metabolome-wide association analysis in 13,596 participants from five European population-based cohorts characterized for depression, and circulating metabolites using ultra high-performance liquid chromatography/tandem accurate mass spectrometry (UHPLC/MS/MS) based Metabolon platform. We tested 806 metabolites covering a wide range of biochemical processes including those involved in lipid, amino-acid, energy, carbohydrate, xenobiotic and vitamin metabolism for their association with depression. In a conservative model adjusting for life style factors and cardiovascular and antidepressant medication use we identified 8 metabolites, including 6 novel, significantly associated with depression. In individuals with depression, increased levels of retinol (vitamin A), 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1) (lecithin) and mannitol/sorbitol and lower levels of hippurate, 4-hydroxycoumarin, 2-aminooctanoate (alpha-aminocaprylic acid), 10-undecenoate (11:1n1) (undecylenic acid), 1-linoleoyl-GPA (18:2) (lysophosphatidic acid; LPA 18:2) are observed. These metabolites are either directly food derived or are products of host and gut microbial metabolism of food-derived products. Our Mendelian randomization analysis suggests that low hippurate levels may be in the causal pathway leading towards depression. Our findings highlight putative actionable targets for depression prevention that are easily modifiable through diet interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.