SynthesisAddiction (Abingdon, England)2023
The impact of cannabis legalization and decriminalization on acute poisoning: A systematic review.
Synthesis in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of cannabis legalization and decriminalization on acute poisoning: A systematic review.Addiction (Abingdon, England) · 2023Pooled it
- Change of substance-related hospitalisation in adolescents after cannabis legalisation in Thailand in 2022.Addiction (Abingdon, England) · 2026Article
- Impact of partial cannabis legalisation in Luxembourg: An interdisciplinary perspective.Drug and alcohol dependence reports · 2026Article
- Increase in Cannabis-Specific Hospital Admissions After Partial Legalization in Germany: A Nationwide Time-Series Analysis.Deutsches Arzteblatt international · 2026Observational
- Behavioral and Self-Report Cognitive Impairment Differences between Fast-Acting, Standard, and Placebo Cannabis Edibles.Research square · 2026Article
- Adverse Effects of Non-Medical Use of Cannabis or Opioids Associated with Adverse Childhood Experiences.International journal of environmental research and public health · 2026Article
- Impact of legalization on cannabis exposure calls to the British Columbia Poison Control Centre.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Association of State Cannabis Legalization With Cannabis Use Disorder and Cannabis Poisoning.JAMA psychiatry · 2025Article
- Cannabis poisonings in Australia following the legalisation of medicinal cannabis, 2014-24: analysis of NSW Poisons Information Centre data.The Medical journal of Australia · 2025Article
- Commentary on Darke et al.: Expanded psychedelic access requires new safety monitoring systems.Addiction (Abingdon, England) · 2024Article
- Patterns and Emerging Trends in Acute Poisoning with Substances of Abuse Used for Recreational Purposes in Adolescents: A Six-Year Multicentre Study.Life (Basel, Switzerland) · 2024Article
- Cannabis and children: risk mitigation strategies for edibles.Frontiers in psychiatry · 2024Review
- Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram.Frontiers in public health · 2024Article
- Commentary on Allaf et al.: Comparing countries with different legal cannabis markets can inform on the impact of regulating product type and potency.Addiction (Abingdon, England) · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMany countries have recently legalized medicinal and recreational cannabis. With increasing use and access come the potential for harms. We aimed to examine the effect of cannabis legalization/decriminalization on acute poisoning.
methodsA systematic review and meta-analysis registered with PROSPERO (CRD42022323437). We searched Embase, Medline, Scopus and Cochrane Central Register of Controlled Trials from inception to March 2022. No restrictions on language, age or geography were applied. Abstracts from three main clinical toxicology conferences were hand-searched. Included studies had to report on poisonings before and after changes in cannabis legislation, including legalization and decriminalization of medicinal and recreational cannabis. Where possible, relative risk (RR) of poisoning after legalization (versus before) was calculated and pooled. Risk of bias was assessed with ROBINS-I.
resultsOf the 1065 articles retrieved, 30 met inclusion criteria (including 10 conference abstracts). Studies used data from the United States, Canada and Thailand. Studies examined legalization of medicinal cannabis (n = 14) and decriminalization or legalization of recreational cannabis (n = 21). Common data sources included poisons centre records (n = 18) and hospital presentations/admissions (n = 15, individual studies could report multiple intervention types and multiple data sources). Most studies (n = 19) investigated paediatric poisoning. Most (n = 24) reported an increase in poisonings; however, the magnitude varied greatly. Twenty studies were included in quantitative analysis, with RRs ranging from 0.81 to 29.00. Our pooled estimate indicated an increase in poisoning after legalization [RR = 3.56, 95% confidence interval (CI) = 2.43-5.20], which was greater in studies that focused on paediatric patients (RR = 4.31, 95% CI = 2.30-8.07).
conclusionsMost studies on the effect of medicinal or recreational cannabis legalization/decriminalization on acute poisoning reported a rise in cannabis poisoning after legalization/decriminalization. Most evidence is from US legalization, despite legalization and decriminalization in many countries.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.