ArticlebioRxiv : the preprint server for biology2023
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology.
Jared A Tangeman, Sofia M Rebull, Erika Grajales-Esquivel, Jacob M Weaver, Stacy Bendezu-Sayas, Michael L Robinson, Salil A Lachke, Katia Del Rio-Tsonis
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 1 country.
Jared A TangemanDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Sofia M RebullDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Erika Grajales-EsquivelDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Jacob M WeaverDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Stacy Bendezu-SayasDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Michael L RobinsonDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Salil A LachkeDepartment of Biological Sciences, University of Delaware, Newark, DE 19716 USA.
Katia Del Rio-TsonisDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056 USA.
Miami University · USUniversity of Delaware · US
Funding
POST TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN THE LENS (LENS GENE EXPRESSIONR01EY021505 · NEI · WASHINGTON UNIVERSITY · PI LACHKE, SALIL · 2011 to 2024
$5.3MThe role of Injury signals in RPE ReprogrammingR01EY026816 · NEI · MIAMI UNIVERSITY OXFORD · PI DEL RIO-TSONIS, KATIA · 2016 to 2020
$1.8MRNA-binding proteins in early eye development.R01EY029770 · NEI · UNIVERSITY OF DELAWARE · PI LACHKE, SALIL · 2019 to 2023
$1.7MRegulation of the lens transcriptome and chromatin architecture by FOXE3R21EY033471 · NEI · MIAMI UNIVERSITY OXFORD · PI ROBINSON, MICHAEL L · 2022 to 2023
$397kInvestigating the role of NKX6-1 in secondary lens fiber cell differentiationR21EY031092 · NEI · MIAMI UNIVERSITY OXFORD · PI ROBINSON, MICHAEL L · 2020 to 2021
$392kElucidating the gene regulatory networks that drive neural regenerationF99NS129167 · NINDS · MIAMI UNIVERSITY OXFORD · PI TANGEMAN, JARED A · 2022 to 2022
$41kNEI NIH HHS R01 EY021505NEI NIH HHS R01 EY026816NEI NIH HHS R01 EY029770NEI NIH HHS R21 EY031092NEI NIH HHS R21 EY033471NINDS NIH HHS F99 NS129167
6 · The paper itselfAbstract
Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause congenital cataract. We report the first single-cell multiomic atlas of lens development, leveraging snRNA-seq, snATAC-seq, and CUT&RUN-seq to discover novel mechanisms of cell fate determination and cataract-linked regulatory networks. A comprehensive profile of
Identifiers
PMID37502967
PMCPMC10369908
OpenAlexW4383955905
What Socratic holds
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