Evidence map›Paper›PMID 37503198›Full record

ArticlebioRxiv : the preprint server for biology2024

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy Short: Magnetogenetic Regulation of Motor Circuits.

Santiago R Unda, Lisa E Pomeranz, Roberta Marongiu, Xiaofei Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, George Vaisey, Putianqi Wang, Jonathan P Dyke and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 4 countries.

Santiago R UndaLaboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, Cornell University; New York, NY, USA.ORCID 0000-0001-7319-6794
Lisa E PomeranzLaboratory of Molecular Genetics, Rockefeller University; New York, NY, USA.
Roberta MarongiuLaboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, Cornell University; New York, NY, USA.
Xiaofei YuSchool of Life Sciences, Fudan University, Shanghai, 200433.ORCID 0000-0002-1712-331X
Leah KellyLaboratory of Molecular Genetics, Rockefeller University; New York, NY, USA.
Gholamreza HassanzadehVIB Nanobody Core, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels.
Henrik MolinaDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
George VaiseyLaboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10065, USA.
Putianqi WangLaboratory of Molecular Genetics, Rockefeller University; New York, NY, USA.
Jonathan P DykeCitigroup Bioimaging Center, Weill Cornell Medical College, Cornell University; New York, NY, USA.ORCID 0000-0001-7170-488X
Edward K FungCitigroup Bioimaging Center, Weill Cornell Medical College, Cornell University; New York, NY, USA.
Logan GrosenickDepartment of Psychiatry, Weill Cornell Medical College, Cornell University; New York, NY, USA.
Rick ZirkelMeining School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Aldana M AntoniazziLaboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, Cornell University; New York, NY, USA.
Sofya NormanLaboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, Cornell University; New York, NY, USA.
Conor M ListonDepartment of Psychiatry, Weill Cornell Medical College, Cornell University; New York, NY, USA.
Chris SchafferMeining School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-7800-9596
Nozomi NishimuraMeining School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Sarah A StanleyDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeffrey M FriedmanLaboratory of Molecular Genetics, Rockefeller University; New York, NY, USA.
Michael G KaplittLaboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, Cornell University; New York, NY, USA.ORCID 0000-0002-8979-2459
Cornell University · USRockefeller University · USCitigroup · USLaboratory of Molecular Genetics · PLAllen Institute for Brain Science · USFudan University · CNIcahn School of Medicine at Mount Sinai · USVrije Universiteit Brussel · BE

Funding

Remote Electromagnetic Control of Neural Activity for Treatment of Parkinson's DiseaseR01NS097184 · NINDS · ROCKEFELLER UNIVERSITY · PI DORDICK, JONATHAN S., FRIEDMAN, JEFFREY M · 2016 to 2020
$3.4M
NINDS NIH HHS R01 NS097184
6 · The paper itself

Abstract

Here we report a novel suite of magnetogenetic tools, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. AAV-mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine 2a receptor-cre driver mice resulted in motor freezing when placed in an MRI or adjacent to a transcranial magnetic stimulation (TMS) device. Functional imaging and fiber photometry both confirmed activation of the target region in response to the magnetic fields. Expression of the same construct in the striatum of wild-type mice along with a second injection of an AAVretro expressing cre into the globus pallidus led to similar circuit specificity and motor responses. Finally, a mutation was generated to gate chloride and inhibit neuronal activity. Expression of this variant in subthalamic nucleus in PitX2-cre parkinsonian mice resulted in reduced local c-fos expression and motor rotational behavior. These data demonstrate that magnetogenetic constructs can bidirectionally regulate activity of specific neuronal circuits non-invasively

Identifiers

PMID37503198
PMCPMC10369996
OpenAlexW4384405310

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.