Evidence map›Paper›PMID 37504086›Full record

ArticleBiosensors2023

Intensity-Based Camera Setup for Refractometric and Biomolecular Sensing with a Photonic Crystal Microfluidic Chip.

Fabio Aldo Kraft, Stefanie Lehmann, Carmela Di Maria, Leonie Joksch, Stefanie Fitschen-Östern, Sabine Fuchs, Francesco Dell'Olio, Martina Gerken

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Fabio Aldo KraftIntegrated Systems and Photonics, Faculty of Engineering, Kiel University, 24118 Kiel, Germany.
Stefanie LehmannIntegrated Systems and Photonics, Faculty of Engineering, Kiel University, 24118 Kiel, Germany.ORCID 0009-0008-2477-0356
Carmela Di MariaIntegrated Systems and Photonics, Faculty of Engineering, Kiel University, 24118 Kiel, Germany.
Leonie JokschIntegrated Systems and Photonics, Faculty of Engineering, Kiel University, 24118 Kiel, Germany.
Stefanie Fitschen-ÖsternExperimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Kiel University, 24105 Kiel, Germany.
Sabine FuchsExperimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Kiel University, 24105 Kiel, Germany.ORCID 0000-0001-7053-5893
Francesco Dell'OlioDepartment of Electrical and Information Engineering, Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0001-9874-5008
Martina GerkenIntegrated Systems and Photonics, Faculty of Engineering, Kiel University, 24118 Kiel, Germany.ORCID 0000-0002-4234-7833
Christian-Albrechts-Universität zu Kiel · DEPolytechnic University of Bari · IT

Funding

German Federal Ministry of Economic Affairs and Climate Action (BMWK) ZF4558806SB9
6 · The paper itself

Abstract

Label-free sensing is a promising approach for point-of-care testing devices. Among optical transducers, photonic crystal slabs (PCSs) have positioned themselves as an inexpensive yet versatile platform for label-free biosensing. A spectral resonance shift is observed upon biomolecular binding to the functionalized surface. Commonly, a PCS is read out by a spectrometer. Alternatively, the spectral shift may be translated into an intensity change by tailoring the system response. Intensity-based camera setups (IBCS) are of interest as they mitigate the need for postprocessing, enable spatial sampling, and have moderate hardware requirements. However, they exhibit modest performance compared with spectrometric approaches. Here, we show an increase of the sensitivity and limit of detection (LOD) of an IBCS by employing a sharp-edged cut-off filter to optimize the system response. We report an increase of the LOD from (7.1 ± 1.3) × 10

Indexed as

Biosensing TechniquesLimit of DetectionMicrofluidicsOptics and PhotonicsRefractometrybiochiplabel-freemicrofluidicsphotonic crystal slabpoint-of-care

Identifiers

PMID37504086
PMCPMC10377058
OpenAlexW4382202419

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.