Evidence mapPaperPMID 37505703Full record

ArticleToxins2023

Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced by

Armando Reyes, Joseph D Hatcher, Emelyn Salazar, Jacob Galan, Anton Iliuk, Elda E Sanchez, Montamas Suntravat

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Armando ReyesNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Joseph D HatcherNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.ORCID 0009-0009-2573-2666
Emelyn SalazarNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.ORCID 0000-0001-9996-1116
Jacob GalanDepartment of Human Genetics, The University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78539, USA.ORCID 0000-0003-3304-0474
Anton IliukTymora Analytical Operations, West Lafayette, IN 47906, USA.ORCID 0000-0002-2914-1363
Elda E SanchezNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Montamas SuntravatNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.ORCID 0000-0001-8955-7806
Texas A&M University – Kingsville · USThe University of Texas Rio Grande Valley · USTymora Analytical Operations (United States) · US

Funding

Viper Resource Grant at Texas A&M University-KingsvilleP40OD010960 · OD · TEXAS A&M UNIVERSITY-KINGSVILLE · 2024 to 2025
$1.7M
NCI NIH HHS R44 CA239845NHLBI NIH HHS R15 HL137134NIH HHS P40 OD010960
6 · The paper itself

Abstract

Increased vascular permeability is a frequent outcome of viperid snakebite envenomation, leading to local and systemic complications. We reported that snake venom cysteine-rich secretory proteins (svCRiSPs) from North American pit vipers increase vascular permeability both in vitro and in vivo. They also induce acute activation of several adhesion and signaling molecules that may play a critical role in the pathophysiology of snakebites. Extracellular vesicles (EVs) have gained interest for their diverse functions in intercellular communication, regulating cellular processes, blood-endothelium interactions, vascular permeability, and immune modulation. They also hold potential as valuable biomarkers for diagnosing, predicting, and monitoring therapeutic responses in different diseases. This study aimed to identify proteins in peritoneal exudate and plasma EVs isolated from BALB/c mice following a 30 min post-injection of

Indexed as

Crotalid VenomsSnake BitesAnimalsChromatography, LiquidCrotalusCysteineExudates and TransudatesMiceProteomicsTandem Mass SpectrometryVenomous SnakesCrotalid VenomsCysteineextracellular vehicles (EVs)proteomic analysissnakebitessnake venom cysteine-rich secretory proteins (svCRiSPs)vascular permeability

Identifiers

PMID37505703
PMCPMC10467150
OpenAlexW4382982822

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.