Evidence map›Paper›PMID 37507231›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.

Alice Meng, Dominique Ameroso, Maribel Rios

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Metabotropic glutamate receptor 5 is associated with plasma GFAP dependent on age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Astrocyte involvement in metabolic regulation and disease.Trends in endocrinology and metabolism: TEM · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alice MengGraduate Program in Cell, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111.
Dominique AmerosoGraduate Program in Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111, United States.
Maribel RiosGraduate Program in Cell, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111 maribel.rios@tufts.edu.
Tufts University · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Michael Stafford · 2012 to 2026
$29.3M
BDNF signaling in VMH astrocytes mediating energy and glucose balance controlR01DK117935 · NIDDK · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2019 to 2022
$2.2M
Sex-specific effects of mGluR5 in the VMH influencing glucose homeostasisR01DK113445 · NIDDK · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2017 to 2019
$1.5M
Research Training Program in Nutrition, Obesity and Metabolic DisordersT32DK124170 · NIDDK · TUFTS UNIVERSITY BOSTON · PI GREENBERG, ANDREW S · 2020 to 2024
$870k
Regulation of energy and glucose balance through BDNF signaling in VMH astrocytesF31DK118789 · NIDDK · TUFTS UNIVERSITY BOSTON · PI AMEROSO, DOMINIQUE · 2018 to 2020
$105k
NIDDK NIH HHS F31 DK118789NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK113445NIDDK NIH HHS R01 DK117935NIDDK NIH HHS T32 DK124170
6 · The paper itself

Abstract

The ventromedial hypothalamus (VMH) is a functionally heterogeneous nucleus critical for systemic energy, glucose, and lipid balance. We showed previously that the metabotropic glutamate receptor 5 (mGluR5) plays essential roles regulating excitatory and inhibitory transmission in SF1

Indexed as

Pituitary Adenylate Cyclase-Activating PolypeptideReceptor, Metabotropic Glutamate 5AnimalsAstrocytesFemaleGlucoseHomeostasisHypothalamusLipidsMaleMiceNeuronsVentromedial Hypothalamic NucleusGlucoseGrm5 protein, mouseLipidsPituitary Adenylate Cyclase-Activating PolypeptideReceptor, Metabotropic Glutamate 5astrocytesglucoseglutamatehypothalamusmGluR5

Identifiers

PMID37507231
PMCPMC10436691
OpenAlexW4385335187

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.