Evidence map›Paper›PMID 37508313›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes.

Maria Dehli Vigeland, Siri Tennebø Flåm, Magnus Dehli Vigeland, Ansgar Espeland, Manuela Zucknick, Monica Wigemyr, Lars Christian Haugli Bråten, Elisabeth Gjefsen, John-Anker Zwart, Kjersti Storheim and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Maria Dehli VigelandDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.ORCID 0000-0002-0057-5491
Siri Tennebø FlåmDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Magnus Dehli VigelandFaculty of Medicine, University of Oslo, 0313 Oslo, Norway.
Ansgar EspelandDepartment of Radiology, Haukeland University Hospital, 5021 Bergen, Norway.ORCID 0000-0002-0693-7465
Manuela ZucknickOslo Centre for Biostatistics and Epidemiology, University of Oslo, 0313 Oslo, Norway.
Monica WigemyrDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.
Lars Christian Haugli BråtenDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.
Elisabeth GjefsenDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.
John-Anker ZwartDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.
Kjersti StorheimDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.ORCID 0000-0002-6887-6901
Linda Margareth PedersenDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.ORCID 0000-0002-8448-983X
Kaja SelmerDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.ORCID 0000-0003-4871-112X
Benedicte Alexandra LieFaculty of Medicine, University of Oslo, 0313 Oslo, Norway.
Kristina GervinDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.
The Aim Study GroupDepartment of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, 0450 Oslo, Norway.
Oslo University Hospital · NO

Funding

Klinbeforsk 2017201Southern and Eastern Norway Regional Health Authority 2015090Western Norway Regional Health Authority HV 911938 and HV 911891
6 · The paper itself

Abstract

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (

Indexed as

amoxicillinantibioticsDNA methylationgene expressionimmunoglobulin

Identifiers

PMID37508313
PMCPMC10376514
OpenAlexW4385212772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.