Evidence map›Paper›PMID 37509135›Full record

ArticleBiomolecules2023

Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells.

Thamir M Ismail, Rachel G Crick, Min Du, Uma Shivkumar, Andrew Carnell, Roger Barraclough, Guozheng Wang, Zhenxing Cheng, Weiping Yu, Angela Platt-Higgins and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Thamir M IsmailDepartment of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Rachel G CrickDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Min DuDepartment of Clinical Infection, Microbiology and Immunity, University of Liverpool, Liverpool L69 7ZB, UK.
Uma ShivkumarDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Andrew CarnellDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Roger BarracloughDepartment of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.ORCID 0000-0002-7203-1194
Guozheng WangDepartment of Clinical Infection, Microbiology and Immunity, University of Liverpool, Liverpool L69 7ZB, UK.ORCID 0000-0001-5525-3548
Zhenxing ChengMedical School, Southeast University, Nanjing 230032, China.
Weiping YuMedical School, Southeast University, Nanjing 230032, China.ORCID 0000-0003-3968-3104
Angela Platt-HigginsDepartment of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Gemma NixonDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.ORCID 0000-0002-9730-0960
Philip S RudlandDepartment of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
University of Liverpool · GBAnhui Medical University · CNSoutheast University · CN

Funding

Cancer Research UK C1440/A3019Medical Research Council G0801447
6 · The paper itself

Abstract

Most patients who die of cancer do so from its metastasis to other organs. The calcium-binding protein S100A4 can induce cell migration/invasion and metastasis in experimental animals and is overexpressed in most human metastatic cancers. Here, we report that a novel inhibitor of S100A4 can specifically block its increase in cell migration in rat (IC

Indexed as

S100 Calcium-Binding Protein A4Triple Negative Breast NeoplasmsAnimalsCell Line, TumorCell MovementHumansMiceNeoplasm InvasivenessNeoplasm MetastasisProteolysis Targeting ChimeraRatsProteolysis Targeting ChimeraS100A4 protein, humanS100 Calcium-Binding Protein A4inhibition of migration/metastasisPROTAC destructionS100A4triple negative breast cancer

Identifiers

PMID37509135
PMCPMC10377353
OpenAlexW4383908702

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.