Evidence map›Paper›PMID 37509671›Full record

ArticleBiomedicines2023

Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts.

Michail Spathakis, Gesthimani Tarapatzi, Eirini Filidou, Leonidas Kandilogiannakis, Evangelos Karatzas, Paschalis Steiropoulos, Dimitrios Mikroulis, George M Spyrou, Vangelis G Manolopoulos, George Kolios and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Michail SpathakisLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Gesthimani TarapatziLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-6877-5991
Eirini FilidouLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-7146-4684
Leonidas KandilogiannakisLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-5982-4210
Evangelos KaratzasInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", 16672 Vari, Greece.ORCID 0000-0001-9132-8981
Paschalis SteiropoulosDepartment of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0001-7121-6253
Dimitrios MikroulisDepartment of Cardiothoracic Surgery, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
George M SpyrouBioinformatics Department, The Cyprus Institute of Neurology and Genetics, 2371 Nicosia, Cyprus.ORCID 0000-0002-2470-3363
Vangelis G ManolopoulosLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0849-5469
George KoliosLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-2066-4782
Konstantinos ArvanitidisLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0639-2474
Democritus University of Thrace · GRAlexander Fleming Biomedical Sciences Research Center · GRCyprus Institute of Neurology and Genetics · CY

Funding

"Establishment of a Center of Excellence for Pharmacological Studies and Precision Medicine - IMPReS" (MIS 5047189) which is implemented under the Action "Support for Regional Excellence", funded by the Operational Program "Competitiveness, Entrepreneursh MIS 5047189«Strategic expansion of the Greek Biobanking Infrastructure» (BBMRI-GR) (MIS 5028275) in the framework of the Action "Enhancing Research and Innovation Infrastructure - Second Cycle" MIS 5028275
6 · The paper itself

Abstract

Niclosamide is a commonly used helminthicidic drug for the treatment of human parasitosis by helminths. Recently, efforts have been focusing on repurposing this drug for the treatment of other diseases, such as idiopathic pulmonary fibrosis. Subepithelial lung myofibroblasts (SELMs) isolated from tissue biopsies of patients undergoing surgery for lung cancer were stimulated with TNF-α (50 ng/mL), IL-1α (5 ng/mL), added alone or in combination, and TGF-β

Indexed as

collageninflammationmyofibroblastsniclosamidepulmonary fibrosis

Identifiers

PMID37509671
PMCPMC10377180
OpenAlexW4384932538

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.