Evidence map›Paper›PMID 37510095›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Characterization of Mitochondrial DNA Methylation of Alzheimer's Disease in Plasma Cell-Free DNA.

Binrong Ding, Xuewei Zhang, Zhengqing Wan, Feng Tian, Jie Ling, Jieqiong Tan, Xiaoqing Peng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  15. Mitochondrial One-Carbon Metabolism and Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  16. Review
  17. Mitochondria in Alzheimer's Disease Pathogenesis.Life (Basel, Switzerland) · 2024
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Binrong DingDepartment of Geriatrics, The Third Xiangya Hospital, Central South University, Changsha 410000, China.
Xuewei ZhangHealth Management Center, Xiangya Hospital, Central South University, Changsha 410000, China.
Zhengqing WanHengyang Medical School, University of South China, Hengyang 421001, China.
Feng TianThe 8 Ward, The Ninth Hospital of Changsha, Changsha 410000, China.
Jie LingMedical Functional Experiment Center, School of Basic Medicine, Central South University, Changsha 410000, China.
Jieqiong TanCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China.
Xiaoqing PengCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China.
Central South University · CNNinth Hospital of Nanchang · CNThird Xiangya Hospital · CNUniversity of South China · CNXiangya Hospital Central South University · CN

Funding

Central South University Innovation-Driven Research Programme 2023CXQD066Hunan Provincial Maternal and Child Health Care Hospital KF2021001Natural Science Foundation of Hunan Province 2022JJ30694
6 · The paper itself

Abstract

Noninvasive diagnosis of Alzheimer's disease (AD) is important for patients. Significant differences in the methylation of mitochondrial DNA (mtDNA) were found in AD brain tissue. Cell-free DNA (cfDNA) is a noninvasive and economical diagnostic tool. We aimed to characterize mtDNA methylation alterations in the plasma cfDNA of 31 AD patients and 26 age- and sex-matched cognitively normal control subjects. We found that the mtDNA methylation patterns differed between AD patients and control subjects. The mtDNA was predominantly hypomethylated in the plasma cfDNA of AD patients. The hypomethylation sites or regions were mainly located in mt-rRNA, mt-tRNA, and D-Loop regions. The hypomethylation of the D-Loop region in plasma cfDNA of AD patients was consistent with that in previous studies. This study presents evidence that hypomethylation in the non-protein coding region of mtDNA may contribute to the pathogenesis of AD and potential application for the diagnosis of AD.

Indexed as

Alzheimer’s diseasecell-free DNAmitochondrial DNA methylationnoninvasive diagnosis

Identifiers

PMID37510095
PMCPMC10378411
OpenAlexW4384131098

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.