Evidence map›Paper›PMID 37511122›Full record

ArticleInternational journal of molecular sciences2023

Short Peptides of Innate Immunity Protein Tag7 (PGLYRP1) Selectively Induce Inhibition or Activation of Tumor Cell Death via TNF Receptor.

Daria M Yurkina, Tatiana N Sharapova, Elena A Romanova, Denis V Yashin, Lidia P Sashchenko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. State-of-the-Art Molecular Biophysics in Russia.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daria M YurkinaInstitute of Gene Biology (RAS), Moscow 119334, Russia.
Tatiana N SharapovaInstitute of Gene Biology (RAS), Moscow 119334, Russia.ORCID 0000-0001-5122-7334
Elena A RomanovaInstitute of Gene Biology (RAS), Moscow 119334, Russia.
Denis V YashinInstitute of Gene Biology (RAS), Moscow 119334, Russia.
Lidia P SashchenkoInstitute of Gene Biology (RAS), Moscow 119334, Russia.
Institute of Gene Biology · RU

Funding

Russian Science Foundation 23-14-00076
6 · The paper itself

Abstract

In this study, we have found two peptides of Tag7 (PGLYRP1) protein-17.1A (HRDVQRT) and 17.1B (RSNYVLKG), that have different affinities to the TNFR1 receptor and the Hsp70 protein. Peptide 17.1A is able to inhibit signal transduction through the TNFR1 receptor, and peptide 17.1B can activate this receptor in a complex with Hsp70. Thus, it is possible to modulate the activity of the TNFR1 receptor and further perform its specific inhibition or activation in the treatment of various autoimmune or oncological diseases.

Indexed as

CytokinesNeoplasmsReceptors, Tumor Necrosis Factor, Type IApoptosisHumansImmunity, InnatePeptidesTumor Necrosis Factor-alphaCytokinesPeptidesPGLYRP1 protein, humanReceptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor-alphacytotoxityHsp70short peptidessignal transductionTag7TNFR1

Identifiers

PMID37511122
PMCPMC10379010
OpenAlexW4384385492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.