ArticleLife (Basel, Switzerland)2023
Comparison between Low-Level and High-Intensity Laser Therapy as an Adjunctive Treatment for Knee Osteoarthritis: A Randomized, Double-Blind Clinical Trial.
Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Comparison of the effectiveness of high-intensity laser therapy versus low-level laser therapy in musculoskeletal disorders: a systematic review and network meta-analysis.Lasers in medical science · 2026Pooled it
- The importance of power in photobiomodulation: a systematic review and meta-analysis of high-intensity laser therapy.Frontiers in integrative neuroscience · 2026Pooled it
- Effectiveness of physical therapies for patients with knee osteoarthritis: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Effect Of Photobiomodulation (Low-Level Laser Therapy) In Patients With Knee Osteoarthritis: A Randomized Controlled Trial.Lasers in medical science · 2025Trial
- Dose-optimized HILT promotes peripheral nerve repair through BMP4-Smad9-mediated inhibition of neuroinflammation and oxidative stress.APL bioengineering · 2026Article
- High-Intensity Laser Therapy Versus Extracorporeal Shockwave Therapy for Lateral Elbow Tendinopathy: A Systematic Review and Meta-Analysis.Bioengineering (Basel, Switzerland) · 2026Review
- The effects of various physical modalities on pain in patients with knee osteoarthritis: A network meta-analysis.Journal of orthopaedics · 2025Review
- Article
- Clinical efficacy of ultra-laser irradiation combined with gabapentin on elderly patients with cervical spondylotic radiculopathy.Frontiers in neurology · 2025Article
- A Review of Current Approaches to Pain Management in Knee Osteoarthritis with a Focus on Italian Clinical Landscape.Journal of clinical medicine · 2024Review
- High-Intensity Laser Therapy in Pain Management of Knee Osteoarthritis.Biomedicines · 2024Review
- Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer.Bioengineering (Basel, Switzerland) · 2024Article
- The Effects of High-Intensity Laser Therapy vs. Low-Level Laser Therapy on Functional Ability and Quadriceps Architecture in Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.Journal of lasers in medical sciences · 2024Article
- Current advances of photobiomodulation therapy in treating knee osteoarthritis.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLow-level (LLLT) and high-intensity laser therapy (HILT) can be beneficial additions to knee osteoarthritis (KOA) rehabilitation exercises; however, it is still being determined which electrophysical agent is more effective.
aimTo compare the effects of LLLT and HILT as adjuncts to rehabilitation exercises (LL + EX and HL + EX) on clinical outcomes in KOA.
methodsThirty-four adults with mild-to-moderate KOA were randomly allocated to either LL + EX or HL + EX (
resultsPost intervention, both groups showed improvements in their KOOS, NPRS, active knee flexion, and TUG scores compared to baseline (
conclusionsIncorporating HILT as an adjunct to usual KOA rehabilitation led to significantly higher improvements in pain, physical function, and knee-related disability compared to LLLT applied in scanning mode.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.