Evidence map›Paper›PMID 37512487›Full record

ArticleMetabolites2023

Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.

Rasmus Stenlid, Hannes Manell, Rikard Seth, Sara Y Cerenius, Azazul Chowdhury, Camilla Roa Cortés, Isabelle Nyqvist, Thomas Lundqvist, Maria Halldin, Peter Bergsten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rasmus StenlidDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.ORCID 0000-0002-1586-9310
Hannes ManellDepartment of Women's and Children's Health, Uppsala University, SE75185 Uppsala, Sweden.
Rikard SethDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.
Sara Y CereniusDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.ORCID 0000-0002-3131-2096
Azazul ChowdhuryDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.ORCID 0000-0002-9022-714X
Camilla Roa CortésDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.
Isabelle NyqvistDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.
Thomas LundqvistDepartment of Women's and Children's Health, Karolinska Institute, SE17177 Stockholm, Sweden.
Maria HalldinDepartment of Women's and Children's Health, Karolinska Institute, SE17177 Stockholm, Sweden.
Peter BergstenDepartment of Medical Cell Biology, Uppsala University, SE75123 Uppsala, Sweden.

Funding

Gillbergska Foundation NAGrönberg Foundation NAKarolinska Institute NAStiftelsen Frimurare Barnhuset in Stockholm NAStockholm County Council NASven Jerring Foundation NAUppsala University NA
6 · The paper itself

Abstract

(1) Background: Deficiencies of mitochondrial fatty acid oxidation (FAO) define a subgroup of inborn errors of metabolism, with medium-chain acyl-CoA dehydrogenase deficiency (MCAD) and very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) being two of the most common. Hypoketotic hypoglycemia is a feared clinical complication and the treatment focuses on avoiding hypoglycemia. In contrast, carnitine uptake deficiency (CUD) is treated as a mild disease without significant effects on FAO. Impaired FAO has experimentally been shown to impair glucagon secretion. Glucagon is an important glucose-mobilizing hormone. If and how glucagon is affected in patients with VLCAD or MCAD remains unknown. (2) Methods: A cross-sectional study was performed with plasma hormone concentrations quantified after four hours of fasting. Patients with VLCAD (

Indexed as

carnitine uptake deficiencyglucagonglucagon like peptide-1inborn errors of metabolisminsulinmedium-chain acyl-CoA dehydrogenase deficiencypediatricsvery long-chain acyl-CoA dehydrogenase deficiency

Identifiers

PMID37512487
PMCPMC10386500

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.