Evidence mapPaperPMID 37512560Full record

ArticleMetabolites2023

Baseline Serum Biomarkers Predict Response to a Weight Loss Intervention in Older Adults with Obesity: A Pilot Study.

David H Lynch, Blake R Rushing, Wimal Pathmasiri, Susan McRitchie, Dakota J Batchek, Curtis L Petersen, Danae C Gross, Susan C J Sumner, John A Batsis

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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  6. Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model.Toxicology in vitro : an international journal published in association with BIBRA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

David H LynchDivision of Geriatric Medicine and Center for Aging and Health, University of North Carolina at Chapel Hill, BMBS 5003 Old Clinic/CB #7550, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2512-9367
Blake R RushingNutrition Research Institute, Department of Nutrition, University of North Carolina, Kannapolis, NC 28081, USA.ORCID 0000-0002-8662-3270
Wimal PathmasiriNutrition Research Institute, Department of Nutrition, University of North Carolina, Kannapolis, NC 28081, USA.ORCID 0000-0002-5199-5744
Susan McRitchieNutrition Research Institute, Department of Nutrition, University of North Carolina, Kannapolis, NC 28081, USA.
Dakota J BatchekDivision of Geriatric Medicine and Center for Aging and Health, University of North Carolina at Chapel Hill, BMBS 5003 Old Clinic/CB #7550, Chapel Hill, NC 27599, USA.
Curtis L PetersenGeisel School of Medicine, The Dartmouth Institute for Health Policy, Hanover, NH 03755, USA.
Danae C GrossDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-3892-9408
Susan C J SumnerNutrition Research Institute, Department of Nutrition, University of North Carolina, Kannapolis, NC 28081, USA.
John A BatsisDivision of Geriatric Medicine and Center for Aging and Health, University of North Carolina at Chapel Hill, BMBS 5003 Old Clinic/CB #7550, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0845-4416
University of North Carolina at Chapel Hill · USDartmouth Institute for Health Policy and Clinical Practice · USDavid H. Murdock Research Institute · US

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$8.6M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · UNIV OF NORTH CAROLINA CHAPEL HILL · 1999 to 2025
$5.9M
ACL HHS U48DP005018NCATS NIH HHS UL1 TR001086NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406NIA NIH HHS K23 AG051681NIA NIH HHS K23AG051681NIDDK NIH HHS P30 DK056350NIH HHS UL1TR001086
6 · The paper itself

Abstract

Caloric restriction and aerobic and resistance exercise are safe and effective lifestyle interventions for achieving weight loss in the obese older population (>65 years) and may improve physical function and quality of life. However, individual responses are heterogeneous. Our goal was to explore the use of untargeted metabolomics to identify metabolic phenotypes associated with achieving weight loss after a multi-component weight loss intervention. Forty-two older adults with obesity (body mass index, BMI, ≥30 kg/m

Indexed as

biomarkersolder adultsweight loss intervention

Identifiers

PMID37512560
PMCPMC10385260
OpenAlexW4384665856

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.