Evidence map›Paper›PMID 37513291›Full record

ArticleMolecules (Basel, Switzerland)2023

Two-Dimensional NMR Spectroscopy of the G Protein-Coupled Receptor A

Canyong Guo, Lingyun Yang, Zhijun Liu, Dongsheng Liu, Kurt Wüthrich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Canyong GuoiHuman Institute, ShanghaiTech University, Shanghai 201210, China.ORCID 0009-0007-3474-2458
Lingyun YangiHuman Institute, ShanghaiTech University, Shanghai 201210, China.ORCID 0000-0003-0915-7744
Zhijun LiuNational Facility for Protein Science in Shanghai, ZhangJiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.
Dongsheng LiuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Kurt WüthrichiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
ShanghaiTech University · CNChinese Academy of Sciences · CNScripps Institution of Oceanography · US

Funding

National Natural Science Foundation of China 21904088National Natural Science Foundation of China 31971153
6 · The paper itself

Abstract

Eight hundred and twenty-six human G protein-coupled receptors (GPCRs) mediate the actions of two-thirds of the human hormones and neurotransmitters and over one-third of clinically used drugs. Studying the structure and dynamics of human GPCRs in lipid bilayer environments resembling the native cell membrane milieu is of great interest as a basis for understanding structure-function relationships and thus benefits continued drug development. Here, we incorporate the human A

Indexed as

Lipid BilayersNanostructuresDrug Inverse AgonismHumansMagnetic Resonance SpectroscopyMicellesReceptors, G-Protein-CoupledTryptophanLipid BilayersMicellesReceptors, G-Protein-CoupledTryptophanA2A adenosine receptorGPCRlipid nanodiscssolution NMR

Identifiers

PMID37513291
PMCPMC10383251
OpenAlexW4384557603

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.