Evidence map›Paper›PMID 37513459›Full record

ArticleMolecules (Basel, Switzerland)2023

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer.

Ingryd Nayara de Farias Ramos, Monique Feitosa da Silva, Jefferson Marcio Sanches Lopes, Jordy Neves Cruz, Fabrine Silva Alves, José de Arimatéia Rodrigues do Rego, Marcondes Lima da Costa, Paulo Pimentel de Assumpção, Davi do Socorro Barros Brasil, André Salim Khayat

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Pharmacological Evaluation ofCurrent cancer drug targets · 2026
    Article
  4. Article
  5. Antibiotics (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Review
  8. The Hidden Power of Black Pepper: Exploring Piperine's Role in Cancer.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ingryd Nayara de Farias RamosOncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil.
Monique Feitosa da SilvaOncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil.
Jefferson Marcio Sanches LopesDepartment of Physics, Federal University of Roraima, Boa Vista 69310-000, RR, Brazil.ORCID 0000-0002-3530-347X
Jordy Neves CruzInstitute of Technology, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0003-0529-3714
Fabrine Silva AlvesGraduate Program in Pharmaceutical Innovation, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0002-6602-1942
José de Arimatéia Rodrigues do RegoGraduate Program in Science and Environment, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0003-0891-6438
Marcondes Lima da CostaInstitute of Geosciences, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0002-0134-0432
Paulo Pimentel de AssumpçãoOncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil.
Davi do Socorro Barros BrasilInstitute of Technology, Federal University of Pará, Belém 66075-110, PA, Brazil.
André Salim KhayatOncology Research Center, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0002-3451-6369
Universidade Federal do Pará · BRUniversidade Federal de Roraima · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the

Indexed as

AlkaloidsAntineoplastic AgentsPiper nigrumStomach NeoplasmsBenzodioxolesHumansPiperidinesPolyunsaturated AlkamidesAlkaloidsAntineoplastic AgentsBenzodioxolesPiperidinespiperinePolyunsaturated Alkamidescytotoxicityextraction and purificationgastric cancergreen extractionpiperine

Identifiers

PMID37513459
PMCPMC10385350
OpenAlexW4385161770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.