Evidence map›Paper›PMID 37513524›Full record

ReviewNutrients2023

Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review.

Vicente Javier Clemente-Suárez, Ana Isabel Beltrán-Velasco, Laura Redondo-Flórez, Alexandra Martín-Rodríguez, Rodrigo Yáñez-Sepúlveda, José Francisco Tornero-Aguilera

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Vicente Javier Clemente-SuárezFaculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.ORCID 0000-0002-2397-2801
Ana Isabel Beltrán-VelascoPsychology Department, Faculty of Life and Natural Sciences, Nebrija University, 28240 Madrid, Spain.ORCID 0000-0002-9893-0227
Laura Redondo-FlórezDepartment of Health Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Tajo Street s/n, 28670 Madrid, Spain.ORCID 0000-0002-1006-7642
Alexandra Martín-RodríguezFaculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.ORCID 0000-0002-0087-4379
Rodrigo Yáñez-SepúlvedaFaculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar 2520000, Chile.ORCID 0000-0002-9311-6576
José Francisco Tornero-AguileraFaculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.
Universidad Europea de Madrid · ESUniversidad Andrés Bello · CLUniversidad Nebrija · ESUniversity of the Coast · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This comprehensive narrative review explores the concept of neuro-vulnerability in energy metabolism regulation and its implications for metabolic disorders. The review highlights the complex interactions among the neural, hormonal, and metabolic pathways involved in the regulation of energy metabolism. The key topics discussed include the role of organs, hormones, and neural circuits in maintaining metabolic balance. The review investigates the association between neuro-vulnerability and metabolic disorders, such as obesity, insulin resistance, and eating disorders, considering genetic, epigenetic, and environmental factors that influence neuro-vulnerability and subsequent metabolic dysregulation. Neuroendocrine interactions and the neural regulation of food intake and energy expenditure are examined, with a focus on the impact of neuro-vulnerability on appetite dysregulation and altered energy expenditure. The role of neuroinflammation in metabolic health and neuro-vulnerability is discussed, emphasizing the bidirectional relationship between metabolic dysregulation and neuroinflammatory processes. This review also evaluates the use of neuroimaging techniques in studying neuro-vulnerability and their potential applications in clinical settings. Furthermore, the association between neuro-vulnerability and eating disorders, as well as its contribution to obesity, is examined. Potential therapeutic interventions targeting neuro-vulnerability, including pharmacological treatments and lifestyle modifications, are reviewed. In conclusion, understanding the concept of neuro-vulnerability in energy metabolism regulation is crucial for addressing metabolic disorders. This review provides valuable insights into the underlying neurobiological mechanisms and their implications for metabolic health. Targeting neuro-vulnerability holds promise for developing innovative strategies in the prevention and treatment of metabolic disorders, ultimately improving metabolic health outcomes.

Indexed as

Feeding and Eating DisordersObesityAppetiteEatingEnergy MetabolismHormonesHumansHormoneseating disordersenergy metabolismmetabolic disordersneurobiological mechanismsneuroendocrine interactionsneuroimaging techniquesneuroinflammationneuro-vulnerabilityobesity

Identifiers

PMID37513524
PMCPMC10383861
OpenAlexW4384039654

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.