Evidence map›Paper›PMID 37513667›Full record

SynthesisNutrients2023

What Is the Role of Nutraceutical Products in Cancer Patients? A Systematic Review of Randomized Clinical Trials.

Raffaella Di Napoli, Nunzia Balzano, Annamaria Mascolo, Carla Cimmino, Antonio Vitiello, Andrea Zovi, Annalisa Capuano, Mariarosaria Boccellino

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Berberine shows potential in mitigating PMApoptosis : an international journal on programmed cell death · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Chemopreventive and therapeutic effects ofFrontiers in pharmacology · 2025
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Raffaella Di NapoliCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, Italy.
Nunzia BalzanoCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, Italy.
Annamaria MascoloCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, Italy.
Carla CimminoOrdine Biologi Campania Molise, 80133 Naples, Italy.
Antonio VitielloMinistry of Health, Viale Giorgio Ribotta 5, 00144 Rome, Italy.ORCID 0000-0003-2623-166X
Andrea ZoviMinistry of Health, Viale Giorgio Ribotta 5, 00144 Rome, Italy.ORCID 0000-0002-6528-2171
Annalisa CapuanoCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, Italy.
Mariarosaria BoccellinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-6989-010X
University of Campania "Luigi Vanvitelli" · ITMinistero della Salute · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy represents the main pharmacological cancer treatment. Recently, positive effects emerged with the combination of anticancer therapy and nutraceutical products. The aim of this systematic review is to collect and synthesize the available scientific evidence regarding the potential effects of nutraceuticals on cancer cells. A systematic literature search of randomized clinical trials of nutraceutical products in patients with cancer published up to 15 December 2022 was conducted using three data sources: Embase, PubMed, and Web of Science. The effect of high-dose isoflavone supplements on prostate cancer resulted in stabilization or reduction of PSA concentrations in 50% of isoflavone group patients six months after treatment. High doses of vitamin D supplementation plus chemotherapy in patients with advanced or metastatic colorectal cancer showed a median PFS of 13.0 months (95% CI, 10.1-14.7 months) for 49 patients. The effect of vitamin D supplementation on markers of inflammatory level and antioxidant capacity in women with breast cancer showed a significant increase in serum vitamin D concentration (28 ± 2.6 to 39 ± 3.5;

Indexed as

NeoplasmsVitaminsAntioxidantsDietary SupplementsFemaleHumansMaleRandomized Controlled Trials as TopicVitamin DAntioxidantsVitamin DVitaminscancer patientsnutraceutical productsRCT

Identifiers

PMID37513667
PMCPMC10383141
OpenAlexW4385210830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.