Evidence map›Paper›PMID 37515545›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2023

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders.

Madison N Sluter, Qianqian Li, Nelufar Yasmen, Yu Chen, Lexiao Li, Ruida Hou, Ying Yu, Chao-Yie Yang, Bernd Meibohm, Jianxiong Jiang

Open access · greenAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  4. Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026
    Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Madison N SluterDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-0183-3392
Qianqian LiDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7721-9834
Nelufar YasmenDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Yu ChenDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Lexiao LiDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ruida HouDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ying YuDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Chao-Yie YangDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Bernd MeibohmDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jianxiong JiangDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-3955-8928
University of Tennessee Health Science Center · US

Funding

Inflammatory regulation of neurotrophin signaling in epileptogenesisR01NS100947 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Jianxiong Jiang · 2018 to 2026
$2.8M
Development of first-in-class ST2 inhibitors for treating graft-versus-host diseaseR01HL141432 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PACZESNY, SOPHIE, YANG, CHAO-YIE · 2019 to 2022
$2.6M
Targeting TRPC3 Channels for Epileptic SeizuresR61NS124923 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JIANG, JIANXIONG, LI, WEI · 2022 to 2023
$765k
Targeting Prostaglandin Receptor EP2 for Glioma and Associated EpilepsyR21NS109687 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JIANG, JIANXIONG · 2019 to 2020
$418k
NHLBI NIH HHS R01 HL141432NINDS NIH HHS R01 NS100947NINDS NIH HHS R21 NS109687NINDS NIH HHS R61 NS124923
6 · The paper itself

Abstract

The cyclooxygenase (COX)/prostaglandin E2 (PGE

Indexed as

EpilepsyGliomaStrokeCyclooxygenase 2CytokinesDinoprostoneHumansNeuroinflammatory DiseasesProstaglandin-E SynthasesCyclooxygenase 2CytokinesDinoprostoneProstaglandin-E SynthasesBlood-brain barrier (BBB)cyclooxygenase (COX)epilepsygliomaischemic strokeneurodegenerative diseasesneuroinflammationprostaglandin E synthase (PGES)seizuresstatus epilepticus

Identifiers

PMID37515545
PMCPMC10468642
OpenAlexW4385381999

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.