Evidence map›Paper›PMID 37515673›Full record

ArticleMolecular and cellular biochemistry2024

Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis.

Jian Yang, Xiangyan Li, Yuming Zhang, Pengfei Che, Wei Qin, Xuecui Wu, Yue Liu, Bing Hu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jian Yang *Department of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, No.410, Yiling Avenue, Yichang, 443001, China.
Xiangyan Li *Department of Interventional Catheter Lab, Affiliated Renhe Hospital of China Three Gorges University, Yichang, 443001, China.
Yuming ZhangDepartment of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, No.410, Yiling Avenue, Yichang, 443001, China.
Pengfei CheDepartment of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, No.410, Yiling Avenue, Yichang, 443001, China.
Wei QinDepartment of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, No.410, Yiling Avenue, Yichang, 443001, China.
Xuecui WuDepartment of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, No.410, Yiling Avenue, Yichang, 443001, China.
Yue LiuDepartment of Radiology, Affiliated Renhe Hospital of China Three Gorges University, Yichang, 443001, China.
Bing HuDepartment of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, No.410, Yiling Avenue, Yichang, 443001, China. hubing_32@163.com.
China Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is a dominant pathological basis of cardiovascular disease. Circular RNAs (circRNAs) have been proposed to have crucial functions in regulating pathological progressions of AS. Hence, the aim of this study was to investigate the potential function of circ_0090231 in AS progression. Oxidized low densitylipoprotein (ox-LDL)-challenged vascular smooth muscle cells (VSMCs) were used for in vitro functional analysis. Levels of genes and proteins were measured by qRT-PCR and Western blot. The proliferation, migration and invasion were assessed using cell counting kit-8, 5-ethynyl-2'-deoxyuridine, and transwell assays. The interaction between miR-942-5p and circ_0090231 or PPM1B (Protein Phosphatase, Mg

Indexed as

AtherosclerosisCell MovementCell ProliferationLipoproteins, LDLMicroRNAsMuscle, Smooth, VascularProtein Phosphatase 2CRNA, CircularFemaleGene Knockdown TechniquesHumansMaleMiddle AgedMyocytes, Smooth MuscleLipoproteins, LDLMicroRNAsMIRN942 microRNA, humanoxidized low density lipoproteinPPM1B protein, humanProtein Phosphatase 2CRNA, CircularAtherosclerosisCirc_0090231MiR-942-5pPPM1BVSMC

Identifiers

PMID37515673
OpenAlexW4385380770

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.