Evidence map›Paper›PMID 37516968›Full record

ArticleCell reports2023

Vaccine adjuvant-elicited CD8

Daria L Ivanova, Scott B Thompson, Jared Klarquist, Michael G Harbell, Augustus M Kilgore, Erika L Lasda, Jay R Hesselberth, Christopher A Hunter, Ross M Kedl

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. CD8Cell reports. Medicine · 2026
    Review
  2. Review
  3. Diverse Microbial Exposure Enhances CD8bioRxiv : the preprint server for biology · 2026
    Article
  4. Abnormal Elevation of the Expression of Costimulatory Molecule CD226 in Graves' DiseaseEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daria L IvanovaDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Scott B ThompsonDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Jared KlarquistDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Michael G HarbellDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Augustus M KilgoreDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Erika L LasdaDepartment of Biochemistry & Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Jay R HesselberthDepartment of Biochemistry & Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ross M KedlDepartment of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: ross.kedl@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USUniversity of Pennsylvania · US

Funding

Transcriptional regulation of vaccine-elicited and infection-elicited CD8+ T cell responsesR01AI066121 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Ross M Kedl · 2007 to 2026
$7.1M
Nanopore analysis of transfer RNA forms and functionsR35GM119550 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jay R Hesselberth · 2016 to 2026
$4.5M
Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
Predoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7M
Mechanisms of combined CD40/TLR adjuvant-elicited cellular immunityU01AI160664 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ADAMS, THOMAS A, HUNTER, CHRISTOPHER A · 2021 to 2025
$3.1M
Molecular and cellular basis of Combined Adjuvant-Elicited Cellular ImmunityR01AI126899 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2016 to 2020
$2.5M
CD8 T cell and B cell collaboration following subunit vaccinationR01AI148919 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2020 to 2023
$2.0M
mRNA encoding of immune receptor-targeting antibodies for the augmentation of vaccine-elicited cellular immunity.R21AI171061 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2022 to 2023
$428k
Exploring the heterogeneity of the vaccine-elicited T cell response by scRNAseqR21AI156456 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2021 to 2022
$428k
NIAID NIH HHS R01 AI066121NIAID NIH HHS R01 AI126899NIAID NIH HHS R01 AI148919NIAID NIH HHS R21 AI156456NIAID NIH HHS R21 AI171061NIAID NIH HHS T32 AI074491NIAID NIH HHS U01 AI160664NIGMS NIH HHS R35 GM119550NIGMS NIH HHS T32 GM136444
6 · The paper itself

Abstract

T-bet and FOXO1 are transcription factors canonically associated with effector and memory T cell fates, respectively. During an infectious response, these factors direct the development of CD8

Indexed as

Adjuvants, VaccineCD8-Positive T-LymphocytesAnimalsCell DifferentiationForkhead Box Protein O1Immunologic MemoryListeria monocytogenesMiceMice, Inbred C57BLT-bet Transcription FactorTranscription FactorsAdjuvants, VaccineForkhead Box Protein O1Foxo1 protein, mouseT-bet Transcription FactorTranscription FactorsadjuvantCD8CP: ImmunologyFOXO1T-betT celltranscription factorvaccine

Identifiers

PMID37516968
PMCPMC10577800
OpenAlexW4385391676

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.