Evidence map›Paper›PMID 37517496›Full record

ArticleEnvironmental research2023

Associations between area-level arsenic exposure and adverse birth outcomes: An Echo-wide cohort analysis.

Jonathan V Lewis, Emily A Knapp, Shivani Bakre, Aisha S Dickerson, Theresa M Bastain, Casper Bendixsen, Deborah H Bennett, Carlos A Camargo, Andrea E Cassidy-Bushrow, Elena Colicino and 32 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Interplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Jonathan V LewisDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Emily A KnappDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Shivani BakreDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Aisha S DickersonDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Casper BendixsenMarshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
Deborah H BennettDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Andrea E Cassidy-BushrowDepartment of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
Elena ColicinoDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Viren D'SaDepartment of Pediatrics, Rhode Island Hospital, Providence, RI, USA.
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Sean DeoniBill and Melinda Gates Foundation, Seattle, WA, USA.
Anne L DunlopDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Amy J ElliottAvera Research Institute, Sioux Falls, SD, USA; Department of Pediatrics, University of South Dakota School of Medicine, Vermillion, SD, USA.
Shohreh F FarzanDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Assiamira FerraraDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Rebecca C FryDepartment of Environmental Sciences and Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Tina HartertDepartments of Medicine and Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Caitlin G HoweDartmouth College Geisel School of Medicine, Hanover, NH, USA.
Linda G KahnDepartments of Pediatrics and Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Margaret R KaragasDartmouth College Geisel School of Medicine, Hanover, NH, USA.
Teng-Fei MaDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Daphne Koinis-MitchellDepartment of Pediatrics, Rhode Island Hospital, Providence, RI, USA.
Debra MacKenzieCommunity Environmental Health Program, University of New Mexico College of Pharmacy, Health Sciences Center, Albuquerque, NM, USA.
Luis E MaldonadoDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Francheska M Merced-NievesDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jenae M NeiderhiserDepartment of Psychology, Penn State University, University Park, PA, USA.
Anne E NigraDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Zhongzheng NiuDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Sara S NozadiCommunity Environmental Health Program, College of Pharmacy, Health Sciences Center, Albuquerque, NM, USA.
Zorimar Rivera-NúñezDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, New Brunswick, NJ, USA.
Thomas G O'ConnorDepartments of Psychiatry, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA.
Sarah OsmundsonDepartment of OB/GYN, Vanderbilt University School of Medicine, Nashville, TN, USA.
Amy M PadulaDepartment of Gynecology, Obstetrics and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, CA, USA.
Alicia K PetersonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Allison R SherrisDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Anne StarlingDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Jennifer K StraughenDepartment of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
Rosalind J WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Qi ZhaoDepartment of Preventive Medicine, University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA.
Amii M KressDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: akress1@jhu.edu.
Johns Hopkins University · USUniversity of Southern California · USIcahn School of Medicine at Mount Sinai · USDartmouth College · USHarvard University · USHenry Ford Health System · USKaiser Permanente · USProvidence College · USUniversity of North Carolina at Chapel Hill · USColumbia University · USEmory University · USGates Foundation · USMarshfield Clinic · USNew York University · USPennsylvania State University · USRutgers, The State University of New Jersey · USUniversity of California, Davis · USUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of New Mexico · US

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
NIEHS NIH HHS K01 ES032046NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES023513NIEHS NIH HHS P30 ES030284NIEHS NIH HHS R00 ES030400NIEHS NIH HHS R00 ES030403NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023271NIH HHS UG3 OD023272NIH HHS UG3 OD023275NIH HHS UG3 OD023279NIH HHS UG3 OD023282NIH HHS UG3 OD023289NIH HHS UG3 OD023344NIH HHS UG3 OD023348NIH HHS UG3 OD035509NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035540NIH HHS UH3 OD023248NIH HHS UH3 OD023249NIH HHS UH3 OD023253NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023272NIH HHS UH3 OD023275NIH HHS UH3 OD023279NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023287NIH HHS UH3 OD023288NIH HHS UH3 OD023289NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023313NIH HHS UH3 OD023318NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023337NIH HHS UH3 OD023342NIH HHS UH3 OD023344NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD023349NIH HHS UH3 OD023365NIH HHS UH3 OD023389NIH HHS UH3 OD035509NIH HHS UH3 OD035518
6 · The paper itself

Abstract

backgroundDrinking water is a common source of exposure to inorganic arsenic. In the US, the Safe Drinking Water Act (SDWA) was enacted to protect consumers from exposure to contaminants, including arsenic, in public water systems (PWS). The reproductive effects of preconception and prenatal arsenic exposure in regions with low to moderate arsenic concentrations are not well understood.

objectivesThis study examined associations between preconception and prenatal exposure to arsenic violations in water, measured via residence in a county with an arsenic violation in a regulated PWS during pregnancy, and five birth outcomes: birth weight, gestational age at birth, preterm birth, small for gestational age (SGA), and large for gestational age (LGA).

methodsData for arsenic violations in PWS, defined as concentrations exceeding 10 parts per billion, were obtained from the Safe Drinking Water Information System. Participants of the Environmental influences on Child Health Outcomes Cohort Study were matched to arsenic violations by time and location based on residential history data. Multivariable, mixed effects regression models were used to assess the relationship between preconception and prenatal exposure to arsenic violations in drinking water and birth outcomes.

resultsCompared to unexposed infants, continuous exposure to arsenic from three months prior to conception through birth was associated with 88.8 g higher mean birth weight (95% CI: 8.2, 169.5), after adjusting for individual-level confounders. No statistically significant associations were observed between any preconception or prenatal violations exposure and gestational age at birth, preterm birth, SGA, or LGA.

conclusionsOur study did not identify associations between preconception and prenatal arsenic exposure, defined by drinking water exceedances, and adverse birth outcomes. Exposure to arsenic violations in drinking water was associated with higher birth weight. Future studies would benefit from more precise geodata of water system service areas, direct household drinking water measurements, and exposure biomarkers.

Indexed as

ArsenicDrinking WaterPremature BirthPrenatal Exposure Delayed EffectsBirth WeightChildCohort StudiesFemaleFetal Growth RetardationHumansInfantInfant, NewbornMaternal ExposurePregnancyArsenicDrinking WaterArsenicContaminationDrinking waterPublic water systemsReproductive healthWater violations

Identifiers

PMID37517496
PMCPMC10592196
OpenAlexW4385336899

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.