ArticleAnnals of clinical and translational neurology2023
Association between brain health outcomes and metabolic risk factors in persons with diabetes.
Evan L Reynolds, Kristen Votruba, Clifford R Jack, Richard Beare, Robert I Reid, Gregory M Preboske, Camille Waseta, Rodica Pop-Busui, Robert G Nelson, Brian C Callaghan and 1 more
Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Evan L ReynoldsDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0138-8436
Kristen VotrubaDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Richard BearePeninsula Clinical School, Monash University, Melbourne, Victoria, Australia.
Robert I ReidDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2391-8650
Gregory M PreboskeDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Camille WasetaChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
Rodica Pop-BusuiDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Robert G NelsonChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
Brian C CallaghanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8885-6748
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9162-2694
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Epidemiology, Pathophysiology and Treatment of Diabetic NephropathyZIADK069062 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NELSON, ROBERT G · 2009 to 2023
$10.1M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
NIDDK Diabetic Foot Consortium Clinical Research UnitU01DK119083 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODICA BUSUI (POP-BUSUI), Crystal Murray Holmes · 2018 to 2026
$5.5M
Neural Stem Cell Transplantation: A Novel Cellular Therapy for Alzheimer's DiseaseU01AG057562 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FELDMAN, EVA LUCILLE, MURPHY, GEOFFREY G · 2018 to 2020
$3.5M
Schwann Cell Senescence and the Secretome Provide a Unifying Mechanism for the Onset and Progression of Diabetic NeuropathyR01DK130913 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eva Lucille Feldman, Junguk Hur · 2022 to 2026
$3.3M
The Effect of High Intensity Interval Training and Surgical Weight Loss On Distal Symmetric Polyneuropathy OutcomesR01DK115687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CALLAGHAN, BRIAN CHRISTOPHER · 2018 to 2022
$3.1M
Targeting Inflammation with Salsalate as a Novel Therapy for Diabetic NeuropathyR01DK107956 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUSUI (POP-BUSUI), RODICA, FELDMAN, EVA LUCILLE · 2016 to 2020
$3.0M
UroEDIC Bladder: Bladder Dysfunction in Type 1 DiabetesR01DK116723 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2021 to 2024
$2.5M
Predicting complications of diabetes with longitudinal metabolic trajectoriesR00DK129785 · NIDDK · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Evan L Reynolds · 2024 to 2026
$745k
Predicting complications of diabetes with longitudinal metabolic trajectoriesK99DK129785 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REYNOLDS, EVAN L · 2022 to 2023
We performed a cross-sectional study to determine associations between cognition and MRI-derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): -0.0061, 95%CI: -0.0113, -0.0009, n = 45), gray matter volume (PE: -830.39, 95%CI: -1503.14, -157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
Indexed as
Diabetes Mellitus, Type 2BrainCross-Sectional StudiesHumansMiddle AgedOutcome Assessment, Health CareRisk FactorsUnited States
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Association between brain health outcomes and metabolic risk factors in persons with diabetes. · full record | Socratic