ArticleBiological psychiatry global open science2023
Anxiety Shapes Amygdala-Prefrontal Dynamics During Movie Watching.
Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Identifiable regional and neural network abnormalities in early childhood anxiety.JCPP advances · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Linking subjective experience of anxiety to brain function using natural language processing.Social cognitive and affective neuroscience · 2026Article
- The Relations Among Anxiety, Movie-Watching, and in-Scanner Motion.Human brain mapping · 2025Article
- Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Preliminary evidence for altered brain-heart coherence during anxiogenic movies.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Threat vigilance and intrinsic amygdala connectivity.Human brain mapping · 2022Article
Corrections and comments
- Erratum issuedErratum.2023
Authors and funding
3 authors.
Funding
Abstract
Background: A well-characterized amygdala-dorsomedial prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, engagement of this circuitry within relatively naturalistic paradigms remains unresolved. Methods: Using an open functional magnetic resonance imaging dataset (Cambridge Centre for Ageing Neuroscience; Results: Using an intersubject representational similarity approach, we saw no effect of anxiety when comparing pairwise similarities of dynamic connectivity across the entire movie. However, preregistered analyses demonstrated a relationship between anxiety, amygdala-prefrontal dynamics, and anxiogenic features of the movie (canonical suspense ratings). Our results indicated that amygdala-prefrontal circuitry was modulated by suspense in low-anxiety individuals but was less sensitive to suspense in high-anxiety individuals. We suggest that this could also be related to slowed habituation or amplified anticipation. Moreover, a measure of threat-relevant attentional bias (accuracy/reaction time to fearful faces) demonstrated an association with connectivity and suspense. Conclusions: Overall, this study demonstrated the presence of anxiety-relevant differences in connectivity during movie watching, varying with anxiogenic features of the movie. Mechanistically, exactly how and when these differences arise remains an opportunity for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.