Evidence map›Paper›PMID 37519899›Full record

ArticleiScience2023

AAV-

Tuancheng Feng, Gregory Minevich, Pengan Liu, Henry Xin Qin, Glenn Wozniak, Jenny Pham, Khanh Pham, Akshata Korgaonkar, Michael Kurnellas, Nadine A Defranoux and 3 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Targeting Progranulin as an Immuno-Neurology Therapeutic Approach.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tuancheng FengDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Gregory MinevichAlector Inc, South San Francisco, CA 94080, USA.
Pengan LiuDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Henry Xin QinDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Glenn WozniakAlector Inc, South San Francisco, CA 94080, USA.
Jenny PhamAlector Inc, South San Francisco, CA 94080, USA.
Khanh PhamAlector Inc, South San Francisco, CA 94080, USA.
Akshata KorgaonkarAlector Inc, South San Francisco, CA 94080, USA.
Michael KurnellasAlector Inc, South San Francisco, CA 94080, USA.
Nadine A DefranouxAlector Inc, South San Francisco, CA 94080, USA.
Hua LongAlector Inc, South San Francisco, CA 94080, USA.
Ananya MitraAlector Inc, South San Francisco, CA 94080, USA.
Fenghua HuDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Alector (United States) · USCornell University · US

Funding

Lysosomal Function of Progranulin and NeurodegenerationR01NS095954 · NINDS · CORNELL UNIVERSITY · PI Fenghua Hu · 2017 to 2026
$4.9M
Function of TMEM106B in NeurodegenerationR01NS088448 · NINDS · CORNELL UNIVERSITY · PI HU, FENGHUA · 2014 to 2025
$4.2M
NINDS NIH HHS R01 NS088448NINDS NIH HHS R01 NS095954
6 · The paper itself

Abstract

Loss of function of progranulin (PGRN), encoded by the

Indexed as

Cellular neuroscienceHuman geneticsMolecular neuroscience

Identifiers

PMID37519899
PMCPMC10371829
OpenAlexW4382468037

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.