Evidence map›Paper›PMID 37520249›Full record

ArticlePeerJ2023

Effects of high-risk human papillomavirus infection on P53, pRb, and survivin in lung adenocarcinoma-a retrospective study.

Wenwen Sun, Hui Yang, Lu Cao, Ruochen Wu, Baoqi Ding, Xiaocui Liu, Xinli Wang, Qiang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenwen Sun *Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Hui Yang *Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Lu CaoDepartment of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Ruochen WuDepartment of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Baoqi DingDepartment of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Xiaocui LiuDepartment of Histoloembryology, School of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xinli WangDepartment of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Qiang ZhangShandong First Medical University, Jinan, Shandong, Taian.
Affiliated Hospital of Taishan Medical University · CNShandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To observe the effects of high-risk human papillomavirus (HR-HPV) infection on P53, pRb, and survivin in lung adenocarcinoma (LUAD). Methods: The cancerous and cancer-adjacent tissues of 102 patients with LUAD from January 2020 to April 2022 were selected for the study. HR-HPV infection was detected by flow fluorescence method, and P53, pRb, and survivin protein expression was detected by immunohistochemical staining method. Statistical analysis was performed to determine the differences in the HR-HPV infection and the expression of P53, pRb, and survivin proteins between LUAD tissues and cancer-adjacent tissues; the correlation between HR-HPV infection and P53, pRb, and survivin protein expression in cancer tissues; and the correlation between HR-HPV infection and clinicopathological features of LUAD. Results: The infection rate of HR-HPV was higher in the LUAD tissues (28.43%) than in cancer-adjacent tissues (7.84%), and the difference was statistically significant ( Conclusions: HR-HPV infection was associated with lymph node metastasis and clinical stage of LUAD, which may be achieved by up-regulating p53 and survivin protein expression and down-regulating pRb protein expression.

Indexed as

AdenocarcinomaAdenocarcinoma of LungLung NeoplasmsPapillomavirus InfectionsHuman Papillomavirus VirusesHumansLymphatic MetastasisPrognosisRetrospective StudiesSurvivinTumor Suppressor Protein p53SurvivinTumor Suppressor Protein p53Human papillomavirusLung adenocarcinomaP53PRbSmokingSurvivin

Identifiers

PMID37520249
PMCPMC10386818
OpenAlexW4385321545

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.