Evidence map›Paper›PMID 37520768›Full record

ArticleEuropean journal of radiology open2023

Delta-radiomics in cancer immunotherapy response prediction: A systematic review.

Engy Abbas, Salvatore Claudio Fanni, Claudio Bandini, Roberto Francischello, Maria Febi, Gayane Aghakhanyan, Ilaria Ambrosini, Lorenzo Faggioni, Dania Cioni, Riccardo Antonio Lencioni and 1 more

Open access · goldAbstract read
In one paragraph

Article in European journal of radiology open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 27 citations in OpenAlex.

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  12. MRI and CT radiomics for the diagnosis of acute pancreatitis.European journal of radiology open · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Engy AbbasThe Joint Department of Medical Imaging, University of Toronto, University Health Network, Sinai Health System, Women's College Hospital, 610 University Ave, Toronto, ON, Canada M5G 2M9.
Salvatore Claudio FanniDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Claudio BandiniDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Roberto FrancischelloDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Maria FebiDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Gayane AghakhanyanDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Ilaria AmbrosiniDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Lorenzo FaggioniDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Dania CioniDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Riccardo Antonio LencioniDepartment of Translational Research, Academic Radiology, University of Pisa, Pisa, Italy.
Emanuele NeriThe Joint Department of Medical Imaging, University of Toronto, University Health Network, Sinai Health System, Women's College Hospital, 610 University Ave, Toronto, ON, Canada M5G 2M9.
University of Pisa · ITUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The new immunotherapies have not only changed the oncological therapeutic approach but have also made it necessary to develop new imaging methods for assessing the response to treatment. Delta radiomics consists of the analysis of radiomic features variation between different medical images, usually before and after therapy. Purpose: This review aims to evaluate the role of delta radiomics in the immunotherapy response assessment. Methods: A systematic search was performed in PubMed, Scopus, and Web Of Science using "delta radiomics AND immunotherapy" as search terms. The included articles' methodological quality was measured using the Radiomics Quality Score (RQS) tool. Results: Thirteen articles were finally included in the systematic review. Overall, the RQS of the included studies ranged from 4 to 17, with a mean RQS total of 11,15 ± 4,18 with a corresponding percentage of 30.98 ± 11.61 %. Eleven articles out of 13 performed imaging at multiple time points. All the included articles performed feature reduction. No study carried out prospective validation, decision curve analysis, or cost-effectiveness analysis. Conclusions: Delta radiomics has been demonstrated useful in evaluating the response in oncologic patients undergoing immunotherapy. The overall quality was found law, due to the lack of prospective design and external validation. Thus, further efforts are needed to bring delta radiomics a step closer to clinical implementation.

Indexed as

Delta radiomicsImmunotherapyOncologyRadiomicsRadiomics quality scoreTherapy response evaluation

Identifiers

PMID37520768
PMCPMC10371799
OpenAlexW4385406762

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.