Evidence map›Paper›PMID 37521407›Full record

ArticleFrontiers in cell death2023

Regulators mount up: the metabolic roles of apoptotic proteins.

James H Schofield, Zachary T Schafer

Open access · diamondAbstract read
In one paragraph

Article in Frontiers in cell death, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Frontiers in pharmacology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

James H SchofieldDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.
Zachary T SchaferDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.
University of Notre Dame · US

Funding

Mitophagy-Mediated Cell Death in Mammary TumorigenesisR01CA262439 · NCI · UNIVERSITY OF NOTRE DAME · PI SCHAFER, ZACHARY T. · 2021 to 2025
$2.1M
NCI NIH HHS R01 CA262439
6 · The paper itself

Abstract

The induction of apoptosis, a programmed cell death pathway governed by activation of caspases, can result in fundamental changes in metabolism that either facilitate or restrict the execution of cell death. In addition, metabolic adaptations can significantly impact whether cells in fact initiate the apoptotic cascade. In this mini-review, we will highlight and discuss the interconnectedness of apoptotic regulation and metabolic alterations, two biological outcomes whose regulators are intertwined.

Indexed as

apoptosiscaspasesmetabolismmitochondriaMOMP

Identifiers

PMID37521407
PMCPMC10373711
OpenAlexW4382983294

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.