Evidence map›Paper›PMID 37521647›Full record

ArticleACS omega2023

Structure-Activity Relationships of Triphenylethylene Derivatives and Their Evaluation as Anticancer and Antiviral Agents.

Nermin S Ahmed, Heba E El-Nakib, Marian M Ramsis, Nouran O Albably, Jannette Wober, Jan J Weigand, Kai Schwedtmann, Oliver Zierau, Ashraf H Abadi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Nermin S AhmedFaculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, 11835 Cairo, Egypt.ORCID https://orcid.org/0000-0002-8869-3387
Heba E El-NakibFaculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, 11835 Cairo, Egypt.
Marian M RamsisFaculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, 11835 Cairo, Egypt.
Nouran O AlbablyFaculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, 11835 Cairo, Egypt.
Jannette WoberFaculty of Biology, Institute of Zoology, Technische Universität Dresden, 01062 Dresden, Germany.
Jan J WeigandFaculty of Chemistry and Food Chemistry, Institute of Inorganic Molecular Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.ORCID https://orcid.org/0000-0001-7323-7816
Kai SchwedtmannFaculty of Chemistry and Food Chemistry, Institute of Inorganic Molecular Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.ORCID https://orcid.org/0000-0002-7965-2647
Oliver ZierauFaculty of Biology, Institute of Zoology, Technische Universität Dresden, 01062 Dresden, Germany.
Ashraf H AbadiFaculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, 11835 Cairo, Egypt.ORCID https://orcid.org/0000-0002-7433-261X
German University in Cairo · EGTechnische Universität Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) that is used in the treatment of breast cancer, yet with the risk of developing uterine cancer. A perfect SERM would act as an estrogen activator on bones, the cardiovascular system, and the central nervous system while providing neutral or estrogen blocking effects on the breast and the uterus. Herein, we report on the design, synthesis, and evaluation of new rigid and flexible TAM analogues. Mainly, a chloro substituent is introduced at the para position of the TAM ring

Identifiers

PMID37521647
PMCPMC10373199
OpenAlexW4383903810

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.