Evidence map›Paper›PMID 37522240›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2024

Vaginal morphology and position associated with prolapse recurrence after vaginal surgery: A secondary analysis of the DEMAND study.

Shaniel T Bowen, Pamela A Moalli, Steven D Abramowitch, Douglas H Luchristt, Isuzu Meyer, Charles R Rardin, Heidi S Harvie, Michael E Hahn, Donna Mazloomdoost, Pooja Iyer and 3 more

Open access · greenAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Holistic Pelvic Floor: Pelvic Floor Stress Dysfunction Diseases.International urogynecology journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Shaniel T BowenDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4410-8481
Pamela A MoalliDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Steven D AbramowitchDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Douglas H LuchristtDivision of Urogynecology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-3534-7800
Isuzu MeyerDivision of Urogynecology and Pelvic Reconstructive Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Charles R RardinDivision of Urogynecology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Heidi S HarvieDivision of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Michael E HahnDepartment of Radiology, University of California, San Diego, La Jolla, California, USA.
Donna MazloomdoostEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Pooja IyerBiostatistics Division, PPD Incorporated, San Francisco, California, USA.
Benjamin CarperSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, North Carolina, USA.
Marie G GantzSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, North Carolina, USA.
NICHD Pelvic Floor Disorders Network
University of Pittsburgh · USRTI International · USBrown University · USDuke University · USInstitute for Female Pelvic Medicine and Reconstructive Surgery · USNational Institutes of Health · USPharmaceutical Product Development (United States) · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · US

Funding

Pelvic Floor Disorders Network Data Coordinating Center Administrative Supplement: ODSS CDE FundingU24HD069031 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI MARIE G GANTZ · 2016 to 2026
$35.8M
Pelvic Floor Disorders Network Data Coordinating Center (U01)U01HD069031 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI GANTZ, MARIE G · 2011 to 2015
$19.7M
Perioperative Pelvic Floor Rehab: A Rrandomized TrialU10HD041261 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RICHTER, HOLLY E · 2001 to 2015
$5.1M
UNC Pelvic Floor Disorders Research CollaborativeU10HD041267 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VISCO, ANTHONY G · 2001 to 2015
$5.0M
Pelvic Floor Disorders NetworkU10HD054214 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LUKACZ, EMILY S. · 2006 to 2015
$3.3M
The Cleveland Clinic Clinical SiteU10HD054215 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI BARBER, MATTHEW D · 2006 to 2015
$3.2M
Brown/WIH Pelvic Floor Disorders Network Site (UG1)UG1HD069013 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI Vivian W Sung · 2016 to 2026
$3.1M
Pelvic Floor Disorders Network Clinical Sites (UG1)UG1HD069010 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Heidi S Harvie · 2016 to 2026
$3.0M
Pelvic Floor Disorders Network Clinical Site Application: The San Diego PelvicFloor ConsortiumUG1HD054214 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EMILY S. LUKACZ, Shawn A Menefee · 2016 to 2026
$2.9M
Pelvic Floor Disorders Network Clinical Sites (U10)U10HD069010 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ARYA, LILY A · 2011 to 2015
$1.7M
Brown/WIH Pelvic Floor Disorders Network SiteU10HD069013 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI SUNG, VIVIAN W · 2011 to 2015
$1.6M
Pittsburgh Pelvic Floor Research ProgramU10HD069006 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ZYCZYNSKI, HALINA M · 2011 to 2015
$1.6M
NICHD NIH HHS U01 HD069031NICHD NIH HHS U10 HD041261NICHD NIH HHS U10 HD041267NICHD NIH HHS U10 HD054214NICHD NIH HHS U10 HD054215NICHD NIH HHS U10 HD069006NICHD NIH HHS U10 HD069010NICHD NIH HHS U10 HD069013NICHD NIH HHS U10 HD069025NICHD NIH HHS U24 HD069031NICHD NIH HHS UG1 HD054214NICHD NIH HHS UG1 HD069006NICHD NIH HHS UG1 HD069010NICHD NIH HHS UG1 HD069013
6 · The paper itself

Abstract

objectiveTo identify vaginal morphology and position factors associated with prolapse recurrence following vaginal surgery.

designSecondary analysis of magnetic resonance images (MRI) of the Defining Mechanisms of Anterior Vaginal Wall Descent cross-sectional study.

settingEight clinical sites in the US Pelvic Floor Disorders Network. POPULATION OR SAMPLE: Women who underwent vaginal mesh hysteropexy (hysteropexy) with sacrospinous fixation or vaginal hysterectomy with uterosacral ligament suspension (hysterectomy) for uterovaginal prolapse between April 2013 and February 2015.

methodsThe MRI (rest, strain) obtained 30-42 months after surgery, or earlier for participants with recurrence who desired reoperation before 30 months, were analysed. MRI-based prolapse recurrence was defined as prolapse beyond the hymen at strain on MRI. Vaginal segmentations (at rest) were used to create three-dimensional models placed in a morphometry algorithm to quantify and compare vaginal morphology (angulation, dimensions) and position.

main outcome measuresVaginal angulation (upper, lower and upper-lower vaginal angles in the sagittal and coronal plane), dimensions (length, maximum transverse width, surface area, volume) and position (apex, mid-vagina) at rest.

resultsOf the 82 women analysed, 12/41 (29%) in the hysteropexy group and 22/41 (54%) in the hysterectomy group had prolapse recurrence. After hysteropexy, women with recurrence had a more laterally deviated upper vagina (p = 0.02) at rest than women with successful surgery. After hysterectomy, women with recurrence had a more inferiorly (lower) positioned vaginal apex (p = 0.01) and mid-vagina (p = 0.01) at rest than women with successful surgery.

conclusionsVaginal angulation and position were associated with prolapse recurrence and suggestive of vaginal support mechanisms related to surgical technique and potential unaddressed anatomical defects. Future prospective studies in women before and after prolapse surgery may distinguish these two factors.

Indexed as

Pelvic Organ ProlapseUterine ProlapseCross-Sectional StudiesFemaleGynecologic Surgical ProceduresHumansHysterectomy, VaginalProspective StudiesTreatment OutcomeVaginaangulationdimensionhysterectomyhysteropexyMRIpelvic organ prolapsepositionprolapse recurrencevaginavaginal mesh

Identifiers

PMID37522240
PMCPMC10828105
OpenAlexW4385407079

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.