ArticleProceedings of the National Academy of Sciences of the United States of America2023
Air pollution, genetic susceptibility, and the risk of atrial fibrillation: A large prospective cohort study.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Guangxi Eco-Environmental Health and Aging Study (GEHAS).BMJ open · 2026Article
- Epidemiological and bioinformatics analyses of air pollution and genetic susceptibility in aortic stenosis risk.Nature communications · 2026Article
- Circulating cardiometabolic metabolite profiles associated with ambient air pollution and atrial fibrillation risk: a prospective cohort study.Cardiovascular diabetology · 2026Article
- AI-based multiomics profiling reveals complementary omics contributions to personalized prediction of cardiovascular disease.Nature communications · 2026Article
- Synergistic effects of genetic susceptibility and air pollution on cardiovascular disease.American journal of preventive cardiology · 2026Article
- Plasma proteome mediates the associations between air pollution exposure and disease risk.Nature communications · 2026Article
- Using low-cost sensors and GPS to assess spatiotemporal variations in personal exposure to PMEnvironmental research · 2025Article
- Global, regional, and national burden of atrial fibrillation and atrial flutter in the working-age population from 1990 to 2021: A systematic analysis based on 2021 global burden of disease data.American journal of preventive cardiology · 2025Article
- Association between combined exposure to underground air pollutants and hypertension in coal miners: a cross-sectional study.BMC public health · 2025Article
- Association of air pollution exposure and genetic susceptibility with increased risk of thoracic aortic aneurysm and dissection.Nature cardiovascular research · 2025Article
- Air Pollution and Stroke: An Emerging Challenge From Cardio-Cerebrovascular Multimorbidity.Journal of the American Heart Association · 2025Review
- Air pollution and cardiovascular diseases: mechanisms, evidence, and mitigation strategies.Journal of medicine and life · 2025Review
- Ambient air pollution does not diminish the beneficial effects of active commuting on heart failure: a prospective study in UK Biobank.BMC public health · 2025Article
- A Breath of Trouble: Unraveling the Impact of Air Pollution on Atrial Fibrillation.Journal of clinical medicine · 2024Review
- Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study.Journal of the American Heart Association · 2024Article
- Air pollution, greenspace exposure and risk of Parkinson's disease: a prospective study of 441,462 participants.Journal of neurology · 2024Article
- Review
- Fibrinaloid Microclots and Atrial Fibrillation.Biomedicines · 2024Review
- Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions.Circulation research · 2024Review
- Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson's disease.NPJ Parkinson's disease · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, no study has explored the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of atrial fibrillation (AF). This study was designed to investigate the separate and joint effects of long-term exposure to air pollutants and genetic susceptibility on the risk of AF events. This study included 401,251 participants without AF at baseline from UK Biobank. We constructed a polygenic risk score and categorized it into three categories. Cox proportional hazards models were fitted to assess the separate and joint effects of long-term exposure to air pollutants and genetics on the risk of AF. Additionally, we further evaluated the effect modification of genetic susceptibility. The hazard ratios and corresponding 95% confidence intervals of incident AF for per interquartile range increase in particulate matter with an aerodynamic diameter smaller than 2.5 µm (PM
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.