Evidence map›Paper›PMID 37525862›Full record

ReviewCureus2023

Pathophysiology, Diagnosis, and Management of Takayasu Arteritis: A Review of Current Advances.

Sagar Bhandari, Samia Rauf R Butt, Anzal Ishfaq, Mohamed H Attaallah, Chukwuyem Ekhator, Raghu Halappa Nagaraj, Asmita Mulmi, Muhammad Kamran, Amanda Karski, Karla I Vargas and 8 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06807788 (Evaluation of Platelet Aggregability in Patients with Takayasu's Arteritis), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06807788 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of Platelet Aggregability in Patients with Takayasu's Arteritis

TypeobservationalSponsorJose Carlos NicolauRan2024 to 2027Enrolled100ConditionsTakayasu Arteritis (TAK), Vasculitis, SystemicArmsClopidogrel
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Takayasu arteritis presenting with dysphagia and morning stiffness: a diagnostic challenge in a middle-aged woman.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
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  14. Review
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  17. Endovascular repair of infrarenal aortic aneurysm and severe stenosis in Type V Takayasu arteritis: a rare case report and clinical insights.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sagar BhandariCardiology, Tucson Medical Center, Tucson, USA.
Samia Rauf R ButtGeneral Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Anzal IshfaqInternal Medicine, Mayo Hospital, Lahore, PAK.
Mohamed H AttaallahMedicine, Cairo University, Cairo, EGY.
Chukwuyem EkhatorNeuro-Oncology, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, USA.
Raghu Halappa NagarajSurgery, Avalon University School of Medicine, Willemstad, CUW.
Asmita MulmiMedicine, TMSS Medical College, Bogura, BGD.
Muhammad KamranInternal Medicine, Mayo Hospital, Lahore, PAK.
Amanda KarskiEmergency Medicine, American University of Antigua, Miami, USA.
Karla I VargasMedicine, Universidad Juárez del Estado de Durango, Durango, MEX.
Slobodan LazarevicInternal Medicine, Faculty of Medicine University of Nis, Nis , SRB.
Mohammad Uzair ZamanMedicine, Bacha Khan Medical College, Mardan, PAK.
Gautham Lakshmipriya VetrivendanInternal Medicine, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Kanchipuram, IND.
S M Iram ShahzedInternal Medicine, South Brooklyn Health, Brooklyn, USA.
Archana DasInternal Medicine, North East Medical College and Hospital, Sylhet, BGD.
Vikas YadavInternal Medicine, Pt. Bhagwat Dayal (BD) Sharma Postgraduate Institute of Medical Sciences, Rohtak, IND.
Sophia B BellegardePathology and Laboratory Medicine, American University of Antigua, St. John's, ATG.
Ashraf UllahInternal Medicine, Mayo Hospital, Lahore, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Takayasu arteritis (TA) is a rare, chronic, inflammatory vasculitis that primarily affects large arteries, causing significant morbidity and mortality. This review provides an overview of the pathophysiology, diagnosis, and management of TA based on current advances in the field. TA is characterized by autoimmune-mediated inflammation, vascular remodeling, and endothelial dysfunction. The disease progresses through three stages (active, chronic, and healing phase) each presenting distinct clinical features. Diagnosis of TA can be challenging due to non-specific clinical manifestations and the lack of specific diagnostic tests. Various imaging modalities, such as angiography, ultrasound, and Doppler techniques, play a crucial role in the diagnosis of TA by visualizing arterial involvement and assessing disease extent. Management of TA involves a multidisciplinary approach, with disease-modifying anti-rheumatic drugs (DMARDs) as the cornerstone of medical therapy. Synthetic and biologic DMARDs are used to induce remission, control inflammation, and prevent complications. Non-pharmacologic interventions, such as resistance exercises and curcumin supplementation, show potential benefits. Invasive interventions, including endovascular therapy and open surgery, are used for managing vascular lesions. However, challenges remain in disease understanding and management, including the heterogeneity of disease presentation and the lack of standardized treatment guidelines. The future of TA management lies in precision medicine, utilizing biomarkers and molecular profiling to personalize treatment approaches and improve patient outcomes. Further research is needed to unravel the underlying mechanisms of TA and develop targeted therapies.

Indexed as

pathogenesisreviewrheumatologytakayasu arteritisvascular

Identifiers

PMID37525862
PMCPMC10386905

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.